Ligand id: 4142

Name: AZ11645373

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 127.94
Molecular weight 463.12
XLogP 5.48
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Michel AD, Ng SW, Roman S, Clay WC, Dean DK, Walter DS. (2009)
Mechanism of action of species-selective P2X(7) receptor antagonists.
Br. J. Pharmacol., 156 (8): 1312-25. [PMID:19309360]
2. Stokes L, Jiang LH, Alcaraz L, Bent J, Bowers K, Fagura M, Furber M, Mortimore M, Lawson M, Theaker J et al.. (2006)
Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.
Br. J. Pharmacol., 149 (7): 880-7. [PMID:17031385]