Ligand id: 4841

Name: miglustat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 84.16
Molecular weight 219.15
XLogP -0.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Butters TD, van den Broek LAGM, Fleet GWJ, Krulle TM, Wormald MR, Dwek RA, Platt FM. (2000)
Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis.
Tetrahedron: Assymetry, 11 (1): 113-124.
2. Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM. (2007)
Imino sugars are potent agonists of the human glucose sensor SGLT3.
Mol. Pharmacol., 71 (2): 628-34. [PMID:17110502]