Ligand id: 486

Name: (+)-cyclazosin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 106.95
Molecular weight 437.21
XLogP 2.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Giardina D, Crucianelli M, Romanelli R, Leonardi A, Poggesi E, Melchiorre C. (1996)
Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-1-yl]furan-2-ylmethanone (cyclazosin) a potent competitive alpha-1B adrenoceptor antagonist.
J Med Chem, 39: 4602-4607. [PMID:8917649]