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Synonyms: GDF-9B | growth/differentiation factor 9B
Compound class:
Endogenous peptide in human, mouse or rat
Comment: The BMP-15 gene is X-linked and expressed in oocytes. BMP-15 protein appears to be involved in early ovarian folliculogenesis [1-3], acting in synergy with growth/differentiation factor-9 [4]. BMP-15 is a selective modulator of FSH action [3]. The active peptide is a disulphide bond-linked homodimer.
Species: Human
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| References |
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1. Aaltonen J, Laitinen MP, Vuojolainen K, Jaatinen R, Horelli-Kuitunen N, Seppä L, Louhio H, Tuuri T, Sjöberg J, Bützow R et al.. (1999)
Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis. J Clin Endocrinol Metab, 84 (8): 2744-50. [PMID:10443672] |
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2. Laitinen M, Vuojolainen K, Jaatinen R, Ketola I, Aaltonen J, Lehtonen E, Heikinheimo M, Ritvos O. (1998)
A novel growth differentiation factor-9 (GDF-9) related factor is co-expressed with GDF-9 in mouse oocytes during folliculogenesis. Mech Dev, 78 (1-2): 135-40. [PMID:9858711] |
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3. Otsuka F, Yao Z, Lee T, Yamamoto S, Erickson GF, Shimasaki S. (2000)
Bone morphogenetic protein-15. Identification of target cells and biological functions. J Biol Chem, 275 (50): 39523-8. [PMID:10998422] |
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4. Yan C, Wang P, DeMayo J, DeMayo FJ, Elvin JA, Carino C, Prasad SV, Skinner SS, Dunbar BS, Dube JL et al.. (2001)
Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Mol Endocrinol, 15 (6): 854-66. [PMID:11376106] |
