indoramin

Ligand id: 501

Name: indoramin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 48.13
Molecular weight 347.2
XLogP 5.14
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Daniels DV, Gever JR, Jasper JR, Kava MS, Lesnick JD, Meloy TD, Stepan G, Williams TJ, Clarke DE, Chang DJ, Ford AP. (1999)
Human cloned alpha1A-adrenoceptor isoforms display alpha1L-adrenoceptor pharmacology in functional studies.
Eur J Pharmacol370: 337-343. [PMID:10334511]
2. Ford APDW, Daniels DV, Chang DJ, Gever JR, Jasper JR, Lesnick JD, Clarke DE. (1997)
Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification.
Br. J. Pharmacol.121: 1127-1135. [PMID:9249248]
3. Pierce V, Shepperson NB, Todd MH, Waterfall JF. (1986)
Investigation into the cardioregulatory properties of the alpha 1-adrenoceptor blocker indoramin.
Br. J. Pharmacol.87 (2): 433-41. [PMID:3955309]