Ligand id: 522

Name: guanfacine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 81.47
Molecular weight 245.01
XLogP 1.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Jasper JR, Lesnick JD, Chang LK, Yamanishi SS, Chang TK, Hsu SAO, Daunt DA, Bonhaus DW, Eglen RM. (1998)
Ligand efficacy and potency at recombinant alpha 2 adrenergic receptors - Agonist-mediated [35S]GTPgammaS binding.
Biochem Pharmacol., 55: 1035-1043. [PMID:9605427]
2. MacLennan SJ, Luong LA, Jasper JR, To ZP, Eglen RM. (1997)
Characterization of alpha 2-adrenoceptors mediating contraction of dog saphenous vein: identity with the human alpha 2A subtype.
Br. J. Pharmacol., 121 (8): 1721-9. [PMID:9283709]