AVE 0991

Ligand id: 5579

Name: AVE 0991

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 156.01
Molecular weight 580.18
XLogP 7.2
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Pinheiro SV, Simões e Silva AC, Sampaio WO, de Paula RD, Mendes EP, Bontempo ED, Pesquero JB, Walther T, Alenina N, Bader M et al.. (2004)
Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney.
Hypertension, 44 (4): 490-6. [PMID:15326087]
2. Skiba DS, Nosalski R, Mikolajczyk TP, Siedlinski M, Rios FJ, Montezano AC, Jawien J, Olszanecki R, Korbut R, Czesnikiewicz-Guzik M et al.. (2017)
Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis.
Br. J. Pharmacol., 174 (22): 4055-4069. [PMID:27935022]