Ligand id: 5803

Name: AMG7703

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 70.23
Molecular weight 294.06
XLogP 3.29
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Lee T, Schwandner R, Swaminath G, Weiszmann J, Cardozo M, Greenberg J, Jaeckel P, Ge H, Wang Y, Jiao X et al.. (2008)
Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2.
Mol. Pharmacol., 74 (6): 1599-609. [PMID:18818303]
2. Smith NJ, Ward RJ, Stoddart LA, Hudson BD, Kostenis E, Ulven T, Morris JC, Tränkle C, Tikhonova IG, Adams DR et al.. (2011)
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.
Mol. Pharmacol., 80 (1): 163-73. [PMID:21498659]