compound 7 [PMID: 20638279]

Ligand id: 6232

Name: compound 7 [PMID: 20638279]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 94.73
Molecular weight 243.06
XLogP 2.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. East SP, Bamford S, Dietz MG, Eickmeier C, Flegg A, Ferger B, Gemkow MJ, Heilker R, Hengerer B, Kotey A et al.. (2010)
An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.
Bioorg. Med. Chem. Lett., 20 (16): 4901-5. [PMID:20638279]
2. East SP, Gerlach K. (2010)
mGluR4 positive allosteric modulators with potential for the treatment of Parkinson's disease: WO09010455.
Expert Opin Ther Pat, 20 (3): 441-5. [PMID:20180624]