cyclic CMP

Ligand id: 6261

Name: cyclic CMP

Abbreviated name: cCMP

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 1
Topological polar surface area 153.39
Molecular weight 306.05
XLogP -2.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Bähre H, Hartwig C, Munder A, Wolter S, Stelzer T, Schirmer B, Beckert U, Frank DW, Tümmler B, Kaever V et al.. (2015)
cCMP and cUMP occur in vivo.
Biochem. Biophys. Res. Commun., 460 (4): 909-14. [PMID:25838203]
2. Seifert R. (2015)
cCMP and cUMP: emerging second messengers.
Trends Biochem. Sci., 40 (1): 8-15. [PMID:25435399]
3. Zong X, Krause S, Chen CC, Krüger J, Gruner C, Cao-Ehlker X, Fenske S, Wahl-Schott C, Biel M. (2012)
Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP.
J. Biol. Chem., 287 (32): 26506-12. [PMID:22715094]