Synonyms: PF 4840154 | PF4840154
Compound class:
Synthetic organic
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Ryckmans T, Aubdool AA, Bodkin JV, Cox P, Brain SD, Dupont T, Fairman E, Hashizume Y, Ishii N, Kato T et al.. (2011)
Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel. Bioorg Med Chem Lett, 21 (16): 4857-9. [PMID:21741838] |
2. Samanta A, Kiselar J, Pumroy RA, Han S, Moiseenkova-Bell VY. (2018)
Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition. J Gen Physiol, 150 (5): 751-762. [PMID:29703838] |