compound 34 [PMID: 20409708]

Ligand id: 6321

Name: compound 34 [PMID: 20409708]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 62.56
Molecular weight 350.16
XLogP 5.89
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Brnardic EJ, Fraley ME, Garbaccio RM, Layton ME, Sanders JM, Culberson C, Jacobson MA, Magliaro BC, Hutson PH, O'Brien JA et al.. (2010)
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.
Bioorg. Med. Chem. Lett.20 (10): 3129-33. [PMID:20409708]