D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH2   Click here for help

GtoPdb Ligand ID: 635

Synonyms: analogue #30 [PMID: 19463875]
Compound class: Peptide or derivative
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. González N, Mantey SA, Pradhan TK, Sancho V, Moody TW, Coy DH, Jensen RT. (2009)
Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors.
Peptides, 30 (8): 1473-86. [PMID:19463875]
2. Katsuno T, Pradhan TK, Ryan RR, Mantey SA, Hou W, Donohue PJ, Akeson MA, Spindel ER, Battey JF, Coy DH et al.. (1999)
Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R).
Biochemistry, 38 (22): 7307-20. [PMID:10353842]
3. Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH et al.. (1997)
Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors.
J Biol Chem, 272 (41): 26062-71. [PMID:9325344]
4. Orbuch M, Taylor JE, Coy DH, Mrozinski Jr JE, Mantey SA, Battey JF, Moreau JP, Jensen RT. (1993)
Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues.
Mol Pharmacol, 44 (4): 841-50. [PMID:7901752]
5. Ryan RR, Katsuno T, Mantey SA, Pradhan TK, Weber HC, Coy DH, Battey JF, Jensen RT. (1999)
Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368.
J Pharmacol Exp Ther, 290 (3): 1202-11. [PMID:10454496]
6. Ryan RR, Weber HC, Hou W, Sainz E, Mantey SA, Battey JF, Coy DH, Jensen RT. (1998)
Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3.
J Biol Chem, 273 (22): 13613-24. [PMID:9593699]
7. Ryan RR, Weber HC, Mantey SA, Hou W, Hilburger ME, Pradhan TK, Coy DH, Jensen RT. (1998)
Pharmacology and intracellular signaling mechanisms of the native human orphan receptor BRS-3 in lung cancer cells.
J Pharmacol Exp Ther, 287 (1): 366-80. [PMID:9765358]