tranexamic acid

Ligand id: 6573

Name: tranexamic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 63.32
Molecular weight 157.11
XLogP 0.3
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Shakur H, Elbourne D, G├╝lmezoglu M, Alfirevic Z, Ronsmans C, Allen E, Roberts I. (2010)
The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial.
Trials11: 40. [PMID:20398351]
2. Sperzel M, Huetter J. (2007)
Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation.
J. Thromb. Haemost.5 (10): 2113-8. [PMID:17666018]
3. WOMAN Trial Collaborators. (2017)
Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial.
The Lancet,  Online ahead of print.