compound 22d [PMID: 16242323]

Ligand id: 6731

Name: compound 22d [PMID: 16242323]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 13
Topological polar surface area 129.81
Molecular weight 607.29
XLogP 7.42
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Ban H, Muraoka M, Ioriya K, Ohashi N. (2006)
Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility.
Bioorg. Med. Chem. Lett., 16 (1): 44-8. [PMID:16242323]