azacitidine

Ligand id: 6796

Name: azacitidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 5
Rotatable bonds 2
Topological polar surface area 128.28
Molecular weight 245.09
XLogP -2.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Chen MY, Liao WS, Lu Z, Bornmann WG, Hennessey V, Washington MN, Rosner GL, Yu Y, Ahmed AA, Bast Jr RC. (2011)
Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.
Cancer117 (19): 4424-38. [PMID:21491416]
2. Dear AE. (2016)
Epigenetic Modulators and the New Immunotherapies.
N. Engl. J. Med.374 (7): 684-6. [PMID:26886527]
3. Jones PA, Taylor SM. (1980)
Cellular differentiation, cytidine analogs and DNA methylation.
Cell20 (1): 85-93. [PMID:6156004]
4. Stresemann C, Lyko F. (2008)
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.
Int. J. Cancer123 (1): 8-13. [PMID:18425818]