glipizide

Ligand id: 6821

Name: glipizide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 138.53
Molecular weight 445.18
XLogP 3.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Inagaki N, Gonoi T, Clement JP, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J. (1995)
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Science270 (5239): 1166-70. [PMID:7502040]
2. Miki T, Nagashima K, Seino S. (1999)
The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.
J. Mol. Endocrinol.22 (2): 113-23. [PMID:10194514]
3. Rehmann H. (2012)
Epac2: a sulfonylurea receptor?.
Biochem. Soc. Trans.40 (1): 6-10. [PMID:22260657]