Ligand id: 6901

Name: azilsartan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 114.71
Molecular weight 457.15
XLogP 6.93
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Rakugi H, Nakata E, Sasaki E, Kagawa T. (2014)
Evaluation of the efficacy and tolerability of fixed-dose combination therapy of azilsartan and amlodipine besylate in Japanese patients with grade I to II essential hypertension.
Clin Ther, 36 (5): 711-21. [PMID:24742498]
2. Takahara M, Shiraiwa T, Shindo M, Arai A, Kusuda Y, Katakami N, Kaneto H, Matsuoka TA, Shimomura I. (2014)
Efficacy and safety of 10-mg azilsartan compared with 8-mg candesartan cilexetil in Japanese patients with hypertension: a randomized crossover non-inferiority trial.
Hypertens. Res., 37 (9): 852-7. [PMID:24739538]