Ligand id: 6957

Name: mitotane

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 0
Molecular weight 317.95
XLogP 6.58
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Lehmann TP, Wrzesiński T, Jagodziński PP. (2013)
The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells.
Mol Med Rep, 7 (3): 893-900. [PMID:23254310]
2. Libè R, Fratticci A, Bertherat J. (2007)
Adrenocortical cancer: pathophysiology and clinical management.
Endocr. Relat. Cancer, 14 (1): 13-28. [PMID:17395972]