AM281

Ligand id: 741

Name: AM281

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 59.39
Molecular weight 555.99
XLogP 4.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Henstridge CM, Balenga NA, Schröder R, Kargl JK, Platzer W, Martini L, Arthur S, Penman J, Whistler JL, Kostenis E, Waldhoer M, Irving AJ. (2010)
GPR55 ligands promote receptor coupling to multiple signalling pathways.
Br. J. Pharmacol.160 (3): 604-14. [PMID:20136841]
2. Lan R, Gatley J, Lu Q, Fan P, Fernando SR, Volkow ND, Pertwee R, Makriyannis A. (1999)
Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand.
AAPS Pharmsci.1: E4-null. [PMID:11741201]
3. Ryberg E, Larsson N, Sjögren S, Hjorth S, Hermansson NO, Leonova J, Elebring T, Nilsson K, Drmota T, Greasley PJ. (2007)
The orphan receptor GPR55 is a novel cannabinoid receptor.
Br J Pharmacol152: 1092-1101. [PMID:17876302]