Ligand id: 7551

Name: lofepramine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 23.55
Molecular weight 418.18
XLogP 7.1
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. S├ínchez C, Hyttel J. (1999)
Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.
Cell. Mol. Neurobiol., 19 (4): 467-89. [PMID:10379421]
2. Tatsumi M, Groshan K, Blakely RD, Richelson E. (1997)
Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
Eur. J. Pharmacol., 340 (2-3): 249-58. [PMID:9537821]