example 92 [WO2012095521]

Ligand id: 7856

Name: example 92 [WO2012095521]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 89.6
Molecular weight 394.1
XLogP 2.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Rueeger H et al.. (2012)
Bace-2 inhibitors for the treatment of metabolic disorders.
Patent number: WO2012095521. Assignee: Novartis. Priority date: 03/01/2011. Publication date: 19/07/2012.
2. Southan C. (2013)
BACE2 as a new diabetes target: a patent review (2010 - 2012).
Expert Opin Ther Pat23 (5): 649-63. [PMID:23506624]