dapoxetine

Ligand id: 7901

Name: dapoxetine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 12.47
Molecular weight 305.18
XLogP 7.38
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. ClĂ©ment P, BernabĂ© J, Gengo P, Denys P, Laurin M, Alexandre L, Giuliano F. (2007)
Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine.
Eur. Urol.51 (3): 825-32. [PMID:17064843]
2. Gengo PJ, Giuliano F, McKenna KE et al.. (2005)
Monoaminergic transporter binding and inhibition profile of dapoxetine, a medication for the treatment of premature ejaculation [abstract].
J Urol173: Abstract 878.
3. Kendirci M, Salem E, Hellstrom WJ. (2007)
Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation.
Ther Clin Risk Manag3 (2): 277-89. [PMID:18360636]
4. Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, Miloslavsky M, Kell S, Dapoxetine Study Group. (2006)
Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials.
Lancet368 (9539): 929-37. [PMID:16962882]