dapoxetine

Ligand id: 7901

Name: dapoxetine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 12.47
Molecular weight 305.18
XLogP 7.38
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Clément P, Bernabé J, Gengo P, Denys P, Laurin M, Alexandre L, Giuliano F. (2007)
Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine.
Eur. Urol., 51 (3): 825-32. [PMID:17064843]
2. Gengo PJ, Giuliano F, McKenna KE et al.. (2005)
Monoaminergic transporter binding and inhibition profile of dapoxetine, a medication for the treatment of premature ejaculation [abstract].
J Urol, 173: Abstract 878.
3. Kendirci M, Salem E, Hellstrom WJ. (2007)
Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation.
Ther Clin Risk Manag, 3 (2): 277-89. [PMID:18360636]
4. Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, Miloslavsky M, Kell S, Dapoxetine Study Group. (2006)
Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials.
Lancet, 368 (9539): 929-37. [PMID:16962882]