compound 25 [PMID: 20855207]

Ligand id: 8159

Name: compound 25 [PMID: 20855207]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 124.5
Molecular weight 438.2
XLogP 2.33
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Belanger DB, Williams MJ, Curran PJ, Mandal AK, Meng Z, Rainka MP, Yu T, Shih NY, Siddiqui MA, Liu M et al.. (2010)
Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.
Bioorg. Med. Chem. Lett., 20 (22): 6739-43. [PMID:20855207]