Ligand id: 8378

Name: tafamidis

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 63.33
Molecular weight 306.98
XLogP 3.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Ando Y, Suhr OB. (1998)
Autonomic dysfunction in familial amyloidotic polyneuropathy (FAP).
Amyloid, 5 (4): 288-300. [PMID:10036588]
2. Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR et al.. (2012)
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.
Proc. Natl. Acad. Sci. U.S.A., 109 (24): 9629-34. [PMID:22645360]
3. Foss TR, Wiseman RL, Kelly JW. (2005)
The pathway by which the tetrameric protein transthyretin dissociates.
Biochemistry, 44 (47): 15525-33. [PMID:16300401]
4. Jacobson DR, Pastore RD, Yaghoubian R, Kane I, Gallo G, Buck FS, Buxbaum JN. (1997)
Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans.
N. Engl. J. Med., 336 (7): 466-73. [PMID:9017939]
5. Westermark P, Sletten K, Johansson B, Cornwell 3rd GG. (1990)
Fibril in senile systemic amyloidosis is derived from normal transthyretin.
Proc. Natl. Acad. Sci. U.S.A., 87 (7): 2843-5. [PMID:2320592]