decynium 22

Ligand id: 8482

Name: decynium 22

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 7.12
Molecular weight 327.19
XLogP 7.96
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Engel K, Wang J. (2005)
Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Mol. Pharmacol.68 (5): 1397-407. [PMID:16099839]
2. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H. (1997)
Cloning and characterization of two human polyspecific organic cation transporters.
DNA Cell Biol.16 (7): 871-81. [PMID:9260930]
3. Wang J. (2016)
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Clin. Pharmacol. Ther.100 (5): 489-499. [PMID:27506881]
4. Xia L, Zhou M, Kalhorn TF, Ho HT, Wang J. (2009)
Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity.
Am. J. Physiol. Renal Physiol.296 (6): F1307-13. [PMID:19357181]