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Synonyms: peptide 14 [2]
Compound class:
Peptide or derivative
Comment: Cp40 is a 14 amino acid analogue of the cyclic peptide compstatin [3]. Like compstatin, Cp40 is an inhibitor of complement component C3 (C3). C3 inhibitors are being actively investigated for clinical potential in inflammatory and degenerative diseases [1]. Cp40 has shown effective C3 inhibition in C3 glomerulopathy (C3G) in vitro [3]. C3 glomerulopathies are a group of ultra-rare renal diseases caused by uncontrolled activation of the alternative complement pathway, for which there are no disease-specific treatments.
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| References |
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1. Morgan BP, Harris CL. (2015)
Complement, a target for therapy in inflammatory and degenerative diseases. Nat Rev Drug Discov, 14 (12): 857-77. [PMID:26493766] |
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2. Qu H, Ricklin D, Bai H, Chen H, Reis ES, Maciejewski M, Tzekou A, DeAngelis RA, Resuello RR, Lupu F et al.. (2013)
New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology, 218 (4): 496-505. [PMID:22795972] |
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3. Zhang Y, Shao D, Ricklin D, Hilkin BM, Nester CM, Lambris JD, Smith RJ. (2015)
Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy. Immunobiology, 220 (8): 993-8. [PMID:25982307] |
