ARN-3236

Ligand id: 9581

Name: ARN-3236

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 75.38
Molecular weight 336.09
XLogP 3.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Lombardi MS, GilliĆ©ron C, Dietrich D, Gabay C. (2016)
SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.
J. Leukoc. Biol.99 (5): 711-21. [PMID:26590148]
2. Vankayalapati H, Yerramreddy V, Ganipisetty VB, Talluri S, Appalaneni RP. (2014)
Substituted 1h-pyrrolo [2,3-b] pyridine and 1h-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (sik2) inhibitors.
Patent number: WO2014093383. Assignee: Arrien Pharmaceuticals Llc. Priority date: 14/12/2012. Publication date: 19/06/2014.
3. Zhou J, Alfraidi A, Zhang S, Santiago-O'Farrill JM, Yerramreddy Reddy VK, Alsaadi A, Ahmed AA, Yang H, Liu J, Mao W et al.. (2017)
A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel.
Clin. Cancer Res.23 (8): 1945-1954. [PMID:27678456]