crizotinib

Ligand id: 4903

Name: crizotinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 77.99
Molecular weight 449.12
XLogP 2.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 2,6

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Affinity Units
MET proto-oncogene, receptor tyrosine kinase MET(M1250T) Hs Inhibitor Inhibition 9.3 pKd
MET proto-oncogene, receptor tyrosine kinase MET(Y1235D) Hs Inhibitor Inhibition 8.8 pKd
MET proto-oncogene, receptor tyrosine kinase MET Hs Inhibitor Inhibition 8.7 pKd
ALK receptor tyrosine kinase ALK Hs Inhibitor Inhibition 8.5 pKd
MER proto-oncogene, tyrosine kinase MERTK Hs Inhibitor Inhibition 8.4 pKd
c-ros oncogene 1, receptor tyrosine kinase ROS1 Hs Inhibitor Inhibition 8.4 pKd
EPH receptor B6 EPHB6 Hs Inhibitor Inhibition 8.2 pKd
AXL receptor tyrosine kinase AXL Hs Inhibitor Inhibition 8.1 pKd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(T315I)-phosphorylated Hs Inhibitor Inhibition 8.0 pKd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(T315I)-nonphosphorylated Hs Inhibitor Inhibition 7.9 pKd
Displaying the top 10 targets  View all targets in screen »