casein kinase II inhibitor III

Ligand id: 5941

Name: casein kinase II inhibitor III

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 37.3
Molecular weight 459.69
XLogP 4.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
casein kinase 2, alpha 1 polypeptide subunit CK2/CK2a Hs Inhibitor Inhibition 13.1 12.0 -8.0
Pim-1 proto-oncogene, serine/threonine kinase Pim-1/PIM1 Hs Inhibitor Inhibition 16.2 49.0 6.0
casein kinase 2, alpha prime polypeptide subunit CK2α2/CK2a2 Hs Inhibitor Inhibition 17.0 33.0 5.0
Pim-3 proto-oncogene, serine/threonine kinase Pim-3/PIM3 Hs Inhibitor Inhibition 17.7 78.0 39.0
PAS domain containing serine/threonine kinase PASK/PASK Hs Inhibitor Inhibition 24.8 63.0 6.0
ribosomal protein S6 kinase A3 Rsk2/RSK2 Hs Inhibitor Inhibition 41.2 59.0 43.0
serine/threonine kinase 11 LKB1/LKB1 Hs Inhibitor Inhibition 42.8 93.0 38.0
CDC like kinase 4 nd/CLK4 Hs Inhibitor Inhibition 45.4
polo like kinase 2 Snk/PLK2 Hs Inhibitor Inhibition 51.5 39.0 25.0
Pim-2 proto-oncogene, serine/threonine kinase Pim-2/PIM2 Hs Inhibitor Inhibition 52.8 28.0 1.0
Displaying the top 10 targets  View all targets in screen »