ERK inhibitor II, negative control

Ligand id: 5967

Name: ERK inhibitor II, negative control

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 84.21
Molecular weight 328.11
XLogP 4.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
aurora kinase B Aurora-B/Aurora B Hs Inhibitor Inhibition 5.0 2.0
checkpoint kinase 2 CHK2/CHK2 Hs Inhibitor Inhibition 19.0 11.0
Insulin receptor-related receptor IRR/IRR(INSRR) Hs Inhibitor Inhibition 25.0 2.0
tyrosine kinase non receptor 2 ACK1/ACK1 Hs Inhibitor Inhibition 29.0 14.0
Insulin receptor IR/IR Hs Inhibitor Inhibition 47.0 12.0
colony stimulating factor 1 receptor Fms/FMS Hs Inhibitor Inhibition 49.0 15.0
death associated protein kinase 1 DAPK1/DAPK1 Hs Inhibitor Inhibition 52.0 39.0
mitogen-activated protein kinase 10 JNK3/JNK3 Hs Inhibitor Inhibition 52.0 43.0
maternal embryonic leucine zipper kinase MELK/MELK Hs Inhibitor Inhibition 53.0 36.0
NIMA related kinase 11 NEK11/NEK11 Hs Inhibitor Inhibition 56.0 74.0
Displaying the top 10 targets  View all targets in screen »