Synonyms: example 8 [US20210047309] | GBT-021601 | GBT-601 | GBT021601
Compound class:
Synthetic organic
Comment: Osivelotor (GBT021601; Global Blood Therapeutics) is a clinical lead for the treatment of sickle cell disease. It stablilises sickle haemoglobin (HbS) in its oxygenated state which inhibits its polymerisation (the underlying cause of erythrocyte sickling) [3]. Based on preclinical studies osivelotor is proposed as an oral drug to reduce vaso-occlusive crises in people with sickle cell disease [1].
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Molecular structure representations generated using Open Babel