L-α-methyldopa

Ligand id: 5217

Name: L-α-methyldopa

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 4
Rotatable bonds 3
Topological polar surface area 103.78
Molecular weight 211.08
XLogP -2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1962))
IUPAC Name
(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
International Nonproprietary Names
INN number INN
1110 methyldopa
Synonyms
Aldomet® | Aldoril® | Dopamet® | L-α-Methyl-3,4-dihydroxyphenylalanine
Database Links
CAS Registry No. 555-30-6
ChEBI CHEBI:61058
ChEMBL Ligand CHEMBL459
DrugBank Ligand DB00968
PubChem CID 38853
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Wikipedia Methyldopa
Comments
L-α-methyldopa is metabolised to α-methylnorepinephrine in the brain, the metabolite being a selective agonist of α2 adrenoceptors. Clinical L-α-methyldopa use has largely been replaced by safer alternatives.