romiplostim

Ligand id: 6974

Name: romiplostim

Classification
Compound class Peptide or derivative
Approved drug? Yes (FDA (2008), EMA (2009))
International Nonproprietary Names
INN number INN
8587 romiplostim
Synonyms
MG531 | Nplate®
Database Links
CAS Registry No. 267639-76-9 (source: Scifinder)
ChEMBL Ligand CHEMBL1201832
DrugBank Ligand DB05332
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Wikipedia Romiplostim
Comments
This drug is a thrombopoietin receptor agonist, although its peptide sequence does not resemble that of the endogenous peptide thrombopoietin. Romiplostim is known as a peptibody, a fusion between the Fc portion of immunoglobulin and a therapeutic peptide. In this case the drug exists as a heterodimer. The carboxy terminal 14 amino acid residues of this peptibody constitute the thrombopoietin receptor binding domain (single letter amino acid code: IEGPTLRQWLAARA).