paliperidone

Ligand id: 7258

Name: paliperidone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 69.81
Molecular weight 426.21
XLogP 2.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2006), EMA (2007))
Prodrug risperidone
IUPAC Name
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one
International Nonproprietary Names
INN number INN
7977 paliperidone
Synonyms
9-hydroxyrisperidone | Invega® | Ro-76477 | Ro-92670
Database Links
CAS Registry No. 144598-75-4
ChEMBL Ligand CHEMBL1621
DrugBank Ligand DB01267
PubChem CID 115237
Search Google for chemical match using the InChIKey PMXMIIMHBWHSKN-UHFFFAOYSA-N
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Wikipedia Paliperidone
Comments
Paliperidone is an atypical antipsychotic. Mechanistically it is a dopamine receptor and 5-HT2A receptor antagonist.