ranolazine

Ligand id: 7291

Name: ranolazine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: ranolazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 77.76
Molecular weight 427.25
XLogP 3.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2006), EMA (2008))
IUPAC Name
N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}ethanimidic acid
International Nonproprietary Names
INN number INN
5946 ranolazine
Synonyms
CVT-303 | Ranexa® | RS-43285 | RS-43285-003
Database Links
CAS Registry No. 95635-55-5
ChEMBL Ligand CHEMBL1404
DrugBank Ligand DB00243
PubChem CID 56959
Search Google for chemical match using the InChIKey XKLMZUWKNUAPSZ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone XKLMZUWKNUAPSZ
Search PubMed clinical trials ranolazine
Search PubMed titles ranolazine
Search PubMed titles/abstracts ranolazine
Search UniChem for chemical match using the InChIKey XKLMZUWKNUAPSZ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone XKLMZUWKNUAPSZ
Wikipedia Ranolazine
Comments
The mechanism of action of ranolazine is largely unknown, but may have some antianginal effects by inhibition of the late sodium current in cardiac cells.