tripelennamine

Ligand id: 7318

Name: tripelennamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 19.37
Molecular weight 255.17
XLogP 4.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1948))
IUPAC Name
N-benzyl-N-[2-(dimethylamino)ethyl]pyridin-2-amine
International Nonproprietary Names
INN number INN
1548 tripelennamine
Synonyms
Pyribenzamine®
Database Links
CAS Registry No. 91-81-6
ChEMBL Ligand CHEMBL1241
DrugBank Ligand DB00792
PubChem CID 5587
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Wikipedia tripelennamine
Comments
Tripelennamine is a first-generation antihistamine. It also has serotonin reuptake inhibitor (SRI) activity, and was used as the template molecule in the development of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine. In addition, tripelennamine has dopamine reuptake inhibitor (DRI) activity.