AZD2423

Ligand id: 7825

Name: AZD2423

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 67.92
Molecular weight 411.18
XLogP 1.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-[(2R)-4-tert-butylpiperazine-2-carbonyl]-N-(4-chloro-3-fluorophenyl)piperazine-1-carboxamide
Synonyms
AZD 2423 | AZD-2423
Database Links
GtoPdb PubChem SID 223366156
PubChem CID 46213922
Search Google for chemical match using the InChIKey WERHXSXPOAOBJV-QGZVFWFLSA-N
Search Google for chemicals with the same backbone WERHXSXPOAOBJV
Search UniChem for chemical match using the InChIKey WERHXSXPOAOBJV-QGZVFWFLSA-N
Search UniChem for chemicals with the same backbone WERHXSXPOAOBJV
Comments
AZD2423 is a non-competive negative allosteric modulator of the chemokine receptor CCR2. See the slideset presented by John G Cumming at the 17th RSC/SCI Medicinal Chemistry Symposium, 9th September, 2013, Churchill College, Cambridge [1] for further details of the discovery and molecular mechanism of this compound.
This compound was in the AstraZeneca/NCATS repurposing list from 2012.