ARQ-092

Ligand id: 9429

Name: ARQ-092

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 95.64
Molecular weight 432.21
XLogP 6.62
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
International Nonproprietary Names
INN number INN
10490 miransertib
Synonyms
ARQ 092 | compound 21a [PMID: 27305487] | miransertib (proposed INN)
Database Links
PubChem CID 53262401
RCSB PDB Ligand 6S1
Search Google for chemical match using the InChIKey HNFMVVHMKGFCMB-UHFFFAOYSA-N
Search Google for chemicals with the same backbone HNFMVVHMKGFCMB
Search PubMed clinical trials miransertib
Search PubMed titles miransertib
Search PubMed titles/abstracts miransertib
Search UniChem for chemical match using the InChIKey HNFMVVHMKGFCMB-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone HNFMVVHMKGFCMB
Comments
ARQ-092 is an orally active, selective, and potent allosteric AKT inhibitor [1], being developed for antineoplastic potential.