PF-06650833

Ligand id: 9667

Name: PF-06650833

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 103.54
Molecular weight 361.14
XLogP 2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
compound 40 [PMID: 28498658] | PF06650833
Comments
PF-06650833 is a potent IRAK4 inhibitor identified as a clinical lead [1]. Its pharmacokinetic profile suggests it will be orally bioavailable. Structurally it is an analogue of PF-06426779.
Database Links
GtoPdb PubChem SID 348353626
PubChem CID 118414016
RCSB PDB Ligand 8CG
Search Google for chemical match using the InChIKey JKDGKIBAOAFRPJ-ZBINZKHDSA-N
Search Google for chemicals with the same backbone JKDGKIBAOAFRPJ
Search UniChem for chemical match using the InChIKey JKDGKIBAOAFRPJ-ZBINZKHDSA-N
Search UniChem for chemicals with the same backbone JKDGKIBAOAFRPJ
SynPHARM 84577 (in complex with interleukin 1 receptor associated kinase 4)

Product suppliers

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Tocris
PF 06650833
Cat. No. 6373