Organic anion transporter 4 | Organic anion transporters (OATs) | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

Organic anion transporter 4

Target not currently curated in GtoImmuPdb

Target id: 1030

Nomenclature: Organic anion transporter 4

Systematic Nomenclature: SLC22A11

Family: Organic anion transporters (OATs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 550 11q13.3 SLC22A11 solute carrier family 22 member 11
Previous and Unofficial Names
OAT4 | solute carrier family 22 (organic anion/urate transporter), member 11
Database Links
Specialist databases
Bioparadigms SLC Tables SLC22A11 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
dehydroepiandrosterone sulphate Hs - 1
ochratoxin A Hs - - 1
uric acid Hs - - 2
estrone-3-sulphate Hs - 1
Stoichiometry
Unknown

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
cephalothin Hs Inhibition 6.7 pKi 3
pKi 6.7 (Ki 2x10-7 M) [3]

References

Show »

1. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H. (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J. Biol. Chem., 275 (6): 4507-12. [PMID:10660625]

2. Nigam SK, Bhatnagar V. (2018) The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr. Opin. Nephrol. Hypertens., 27 (4): 305-313. [PMID:29847376]

3. Takeda M, Babu E, Narikawa S, Endou H. (2002) Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur. J. Pharmacol., 438 (3): 137-42. [PMID:11909604]

Contributors

Show »

How to cite this page

Bruno Hagenbuch.
Organic anion transporters (OATs): Organic anion transporter 4. Last modified on 15/02/2019. Accessed on 24/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1030.