Organic anion transporter 4

Target id: 1030

Nomenclature: Organic anion transporter 4

Systematic Nomenclature: SLC22A11

Family: Organic anion transporters (OATs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Organic anion transporter 4 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 550 11q13.3 SLC22A11 solute carrier family 22 member 11
Previous and Unofficial Names
OAT4 | solute carrier family 22 (organic anion/urate transporter), member 11
Database Links
Specialist databases
Bioparadigms SLC Tables SLC22A11 (Hs)
Other databases
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
dehydroepiandrosterone sulphate Hs - 1
ochratoxin A Hs - - 1
estrone-3-sulphate Hs - 1
Stoichiometry
Unknown

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
cephalothin Hs Inhibition 6.7 pKi 2
pKi 6.7 (Ki 2x10-7 M) [2]

References

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1. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H. (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J. Biol. Chem.275 (6): 4507-12. [PMID:10660625]

2. Takeda M, Babu E, Narikawa S, Endou H. (2002) Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur. J. Pharmacol.438 (3): 137-42. [PMID:11909604]

Contributors

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How to cite this page

Bruno Hagenbuch.
Organic anion transporters (OATs): Organic anion transporter 4. Last modified on 05/03/2018. Accessed on 27/04/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1030.