Ornithine decarboxylase

Target id: 1276

Nomenclature: Ornithine decarboxylase

Abbreviated Name: ODC

Family: Decarboxylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Ornithine decarboxylase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 461 2p25 ODC1 ornithine decarboxylase 1
Mouse - 461 12 8.11 cM Odc1 ornithine decarboxylase
Rat - 461 6q16 Odc1 ornithine decarboxylase 1
Previous and Unofficial Names
ODC | RNODC | ornithine decarboxylase, structural 1
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human ornithine decarboxylase at 2.1 angstoms resolution
PDB Id:  1D7K
Resolution:  2.1Å
Species:  Human
References:  1
Enzyme Reaction
EC Number: 4.1.1.17
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
L-ornithine Hs - -
Cofactors
Cofactor Species Comments Reference
pyridoxal phosphate None

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
eflornithine Hs Inhibition 4.9 pKd 2
pKd 4.9 (Kd 1.3x10-5 M) [2]
APA Hs Inhibition 7.5 pIC50 3
pIC50 7.5 (IC50 3.5x10-8 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
Role: 
References:  4

References

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1. Almrud JJ, Oliveira MA, Kern AD, Grishin NV, Phillips MA, Hackert ML. (2000) Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. J. Mol. Biol.295 (1): 7-16. [PMID:10623504]

2. Qu N, Ignatenko NA, Yamauchi P, Stringer DE, Levenson C, Shannon P, Perrin S, Gerner EW. (2003) Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem. J.375 (Pt 2): 465-70. [PMID:12859253]

3. Stanek J, Frei J, Mett H, Schneider P, Regenass U. (1992) 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J. Med. Chem.35 (8): 1339-44. [PMID:1573631]

4. Zell JA, Ziogas A, Ignatenko N, Honda J, Qu N, Bobbs AS, Neuhausen SL, Gerner EW, Anton-Culver H. (2009) Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Clin. Cancer Res.15 (19): 6208-16. [PMID:19789310]

How to cite this page

Decarboxylases: Ornithine decarboxylase. Last modified on 16/04/2015. Accessed on 18/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1276.