Ornithine decarboxylase | Decarboxylases | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

Ornithine decarboxylase

Target not currently curated in GtoImmuPdb

Target id: 1276

Nomenclature: Ornithine decarboxylase

Abbreviated Name: ODC

Family: Decarboxylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 461 2p25 ODC1 ornithine decarboxylase 1
Mouse - 461 12 8.11 cM Odc1 ornithine decarboxylase, structural 1
Rat - 461 6q16 Odc1 ornithine decarboxylase 1
Previous and Unofficial Names
ODC | RNODC | ornithine decarboxylase, structural 1
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human ornithine decarboxylase at 2.1 angstoms resolution
PDB Id:  1D7K
Resolution:  2.1Å
Species:  Human
References:  1
Enzyme Reaction
EC Number:
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
L-ornithine Hs - -
Cofactor Species Comments Reference
pyridoxal 5-phosphate None

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
eflornithine Hs Inhibition 4.9 pKd 2
pKd 4.9 (Kd 1.3x10-5 M) [2]
APA Hs Inhibition 7.5 pIC50 3
pIC50 7.5 (IC50 3.5x10-8 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
References:  4


Show »

1. Almrud JJ, Oliveira MA, Kern AD, Grishin NV, Phillips MA, Hackert ML. (2000) Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. J. Mol. Biol., 295 (1): 7-16. [PMID:10623504]

2. Qu N, Ignatenko NA, Yamauchi P, Stringer DE, Levenson C, Shannon P, Perrin S, Gerner EW. (2003) Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem. J., 375 (Pt 2): 465-70. [PMID:12859253]

3. Stanek J, Frei J, Mett H, Schneider P, Regenass U. (1992) 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J. Med. Chem., 35 (8): 1339-44. [PMID:1573631]

4. Zell JA, Ziogas A, Ignatenko N, Honda J, Qu N, Bobbs AS, Neuhausen SL, Gerner EW, Anton-Culver H. (2009) Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Clin. Cancer Res., 15 (19): 6208-16. [PMID:19789310]

How to cite this page

Decarboxylases: Ornithine decarboxylase. Last modified on 16/04/2015. Accessed on 25/02/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1276.