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Targets
- G protein-coupled receptors
- Ion channels
- Nuclear hormone receptors
- Kinases
- Catalytic receptors
- Transporters
- Enzymes
- Other protein targets
Ligands
- Approved drugs
- Synthetic organics
- Metabolites
- Natural products
- Endogenous peptides
- Other peptides
- Inorganics
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- Labelled ligands
Resources
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What's new to Guide to PHARMACOLOGY
Read our latest Database Report (Apr 2021) - download/view PDF
Database version 2021.1 (18th Mar 21) - read release details in our blog
- GM-CSF added to coronavirus targets lists - a principal marker of severe COVID-19 immunopathology. New coronavirus linked ligands include ensovibep (MP0420), emovododstat & MK-7110.
- 220 ligands since last update, all curated with peptide or chemical structures
- New family of enzymes, Peptidyl-prolyl cis/trans isomerases (PPIases), has been added, including in particular those that are therapeutic targets.
- New download files: Ligands in SDF format and mapping file of GtoPdb ligand IDs to external ligand identifiers - see our downloads page.
- Ligand links to Reactome - both for reactions and drug entities
- Total curated anti-malarial ligands now stands at 105. There are now 37 anti-malarial targets, organised into subfamilies
Coronavirus Information
Coronavirus (Covid-19) Information Page - view our information page which summarises ligands and drug targets relevant in pharmacological strategies to mitigate against COVID-19.
Latest News and Hot Topics in Pharmacology
Pharmacology of COVID-19
Themed issue in BJP
This themed issue includes IUPHAR Review 29: A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development, which made the cover of the issue.
The Concise Guide to PHARMACOLOGY 2019/20
Recent Publications
COVID-19 and the revival of passive immunization: Antibody therapy for inhibiting SARS-CoV-2 and preventing host cell infection: IUPHAR review: 31
Levi-Schaffer F, de Marco A (2021) Br J Pharmacol. Online ahead of print. doi: 10.1111/bph.15359. 
Update of P2X receptor properties and their pharmacology: IUPHAR Review 30
Illes P, Müller CE, Jacobson KA, Grutter T, Nicke A, Fountain SJ, Kennedy C, Schmalzing G, Jarvis MF, Stojilkovic SS, King BF, Di Virgilio F. (2021) Br J Pharmacol. 178(3):489-514. doi: 10.1111/bph.15299.
IUPHAR Review CXI: Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors
Gregory KJ, Goudet C (2021) Pharmacol Rev. 73: 521-569.
IUPHAR Review CX: Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function
Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D (2021) Pharmacol Rev. 73: 310-520.
Pharmacology Education
The IUPHAR Pharmacology Education Project is being developed by IUPHAR with support from ASPET as a learning resource for pharmacology and clinical pharmacology.
synPHARM
SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.
Coronavirus
Our coronavirus information page has details of pharmcological strategies aimed at mitigating against COVID-19. The page also contains links to other useful resources and publications.
Please see our pre-print manuscript on "A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development"
Celebrating >20 years of Servier support
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