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IUPHAR/Servier Fibrosis Symposium

View and read the scientific presentations and report from the IUPHAR/Servier Fibrosis Symposium, held in November 2020.

What's new to Guide to PHARMACOLOGY

Coronavirus (Covid-19) - view our information page


Database version 2021.1 (18th Mar 21) - read release details in our blog

  • GM-CSF added to coronavirus targets lists - a principal marker of severe COVID-19 immunopathology. New coronavirus linked ligands include ensovibep (MP0420), emovododstat & MK-7110.
  • 220 ligands since last update, all curated with peptide or chemical structures
  • New family of enzymes, Peptidyl-prolyl cis/trans isomerases (PPIases), has been added, including in particular those that are therapeutic targets.
  • New download files: Ligands in SDF format and mapping file of GtoPdb ligand IDs to external ligand identifiers - see our downloads page.
  • Ligand links to Reactome - both for reactions and drug entities
  • Total curated anti-malarial ligands now stands at 105. There are now 37 anti-malarial targets, organised into subfamilies

Read our latest Database Report (Nov 2020) - download/view PDF

Latest News and Hot Topics in Pharmacology

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Pharmacology of COVID-19

Themed issue in BJP

BJP COVID-19 Cover

This themed issue includes IUPHAR Review 29: A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development, which made the cover of the issue.

The Concise Guide to PHARMACOLOGY 2019/20

Concise Guide to Pharmacology 2019/20

Access the table of contents go icon to follow link

Please see the 5 minute introductory video on the Concise Guide:

Recent Publications

BJP journal cover

A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development. IUPHAR Review 29

Alexander SPH, Armstrong J, Davenport AP, Davies JA, Faccenda E, Harding SD, Levi-Schaffer F, Maguire JJ, Pawson AJ, Southan C, Spedding MJ (2020) Br J Pharmacol. 177(21):4942-4966. doi: 10.1111/bph.15094. go icon to follow link

Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28

Mariotti FR, Quatrini L, Munari E, Vacca P, Tumino N, Pietra G, Mingari MC, Moretta L (2020) Br J Pharmacol. 177(13):2889-2903. doi: 10.1111/bph.15081. go icon to follow link

Pharm Rev journal cover

IUPHAR Review CXI: Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors

Gregory KJ, Goudet C (2021) Pharmacol Rev. 73: 521-569. go icon to follow link

IUPHAR Review CX: Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D (2021) Pharmacol Rev. 73: 310-520. go icon to follow link

Pharmacology Education

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The IUPHAR Pharmacology Education Project is being developed by IUPHAR with support from ASPET as a learning resource for pharmacology and clinical pharmacology.

synPHARM

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SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.

ELIXIR-UK

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The IUPHAR/BPS Guide to PHARMACOLOGY is one of the ELIXIR-UK node services.

Coronavirus

Our coronavirus information page has details of pharmcological strategies aimed at mitigating against COVID-19. The page also contains links to other useful resources and publications.

Please see our pre-print manuscript on "A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development"

Celebrating >20 years of Servier support

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Servier, a mid-size French Pharmaceutical company, has a long history in pharmacology, and has supported NC-IUPHAR for >20 years with unrestricted educational grants which have permitted the Paris meetings and thus progress of the database.