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An expert-driven guide to pharmacological targets and the substances that act on them.

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What's new to Guide to PHARMACOLOGY

Coronavirus (Covid-19) - view our information page

New database version 2020.4 (24 Sep 2020) - full details in our blog post

Our latest release includes:

We have added a new species page for P. knowlesi
5 new oncology targets, MDM2 proto-oncogene, Ser/Thr protein phosphatase PPM1D, cytidine deaminase/CDA, porcupine O-acyltransferase and HIF-2α (EPAS1) have been added.
Updates have also been made to targets across 35+ different protein families
The list of WHO essential medicines has been expanded with the inclusion of many antibiotics and antivirals
The website tutorial has been updated.

Please read our latest Database Report (April 2020) - download/view PDF

Latest News and Hot Topics in Pharmacology

All news go icon to follow link Our blog Hot topics Latest pairings

GtoMPdb

IUPHAR/MMV Guide to Malaria Pharmacology

Visit the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY portal
Launched in September 2019 to provide optimised access to GtoPdb data for the malaria research community

The Concise Guide to PHARMACOLOGY 2019/20

Access the table of contents

Please see the 5 minute introductory video on the Concise Guide:

Recent Publications

BJP journal cover

A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development. IUPHAR Review 29

Alexander SPH, Armstrong J, Davenport AP, Davies JA, Faccenda E, Harding SD, Levi-Schaffer F, Maguire JJ, Pawson AJ, Southan C, Spedding MJ (2020) Br J Pharmacol. doi: 10.1111/bph.15094.

Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28

Mariotti FR, Quatrini L, Munari E, et al. (2020) Br J Pharmacol. [online ahead of print]. doi: 10.1111/bph.15081.

Pharm Rev journal cover

IUPHAR review article on Differences and Similarities between Human and Rodent Prostaglandin E₂ Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

Norel X, Sugimoto Y, Ozen G, Abdelazeem H, Amgoud Y, Bouhadoun A, Bassiouni W, Goepp M, Mani S, Manikpurage HD, Senbel A, Longrois D, Heinemann A, Yao C, Clapp LH (2020) Pharmacol Rev. 72: 910-968.

IUPHAR review article on Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function

Leach K, Hannan FM, Josephs TM, Keller AN, Møller TC, Ward DT, Kallay E, Mason RS, Thakker RV, Riccardi D, Conigrave AD, Bräuner-Osborne H (2020) Pharmacol Rev. 72: 558-604.

Publication list go icon to follow link

Pharmacology Education

The IUPHAR Pharmacology Education Project is being developed by IUPHAR with support from ASPET as a learning resource for pharmacology and clinical pharmacology.

synPHARM

SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.

ELIXIR-UK

The IUPHAR/BPS Guide to PHARMACOLOGY is one of the ELIXIR-UK node services.

Coronavirus

Our coronavirus information page has details of pharmcological strategies aimed at mitigating against COVID-19. The page also contains links to other useful resources and publications.

Please see our pre-print manuscript on "A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development"

Celebrating >20 years of Servier support

Servier, a mid-size French Pharmaceutical company, has a long history in pharmacology, and has supported NC-IUPHAR for >20 years with unrestricted educational grants which have permitted the Paris meetings and thus progress of the database.