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- G protein-coupled receptors
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Resources
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What's new to Guide to PHARMACOLOGY
Coronavirus (Covid-19) - view our information page
New database version 2020.5 (12 Nov 2020) - full details in our blog post
Our latest release includes:
- Curated some entities from the WHO list of COVID-related therapeutics (October 20): alunacedase alfa, eclitasertib, enpatoran, molnupiravir, nezulcitinib, subasumstat
- New family added: SLC66 Lysosomal amino acid transporters
- New immuno target added: cyclic GMP-AMP synthase (cGAS)
- Total curated Antimalarial ligands familyAnti-malarial ligands now stands at 100!
Please read our latest Database Report (April 2020) - download/view PDF
Latest News and Hot Topics in Pharmacology
Pharmacology of COVID-19
Themed issue in BJP
This themed issue includes IUPHAR Review 29: A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development, which made the cover of the issue.
The Concise Guide to PHARMACOLOGY 2019/20
Recent Publications
A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development. IUPHAR Review 29
Alexander SPH, Armstrong J, Davenport AP, Davies JA, Faccenda E, Harding SD, Levi-Schaffer F, Maguire JJ, Pawson AJ, Southan C, Spedding MJ (2020) Br J Pharmacol. doi: 10.1111/bph.15094. 
Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28
Mariotti FR, Quatrini L, Munari E, et al. (2020) Br J Pharmacol. [online ahead of print]. doi: 10.1111/bph.15081.
IUPHAR review article on Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions
Norel X, Sugimoto Y, Ozen G, Abdelazeem H, Amgoud Y, Bouhadoun A, Bassiouni W, Goepp M, Mani S, Manikpurage HD, Senbel A, Longrois D, Heinemann A, Yao C, Clapp LH (2020) Pharmacol Rev. 72: 910-968.
IUPHAR review article on Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function
Leach K, Hannan FM, Josephs TM, Keller AN, Møller TC, Ward DT, Kallay E, Mason RS, Thakker RV, Riccardi D, Conigrave AD, Bräuner-Osborne H (2020) Pharmacol Rev. 72: 558-604.
Pharmacology Education
The IUPHAR Pharmacology Education Project is being developed by IUPHAR with support from ASPET as a learning resource for pharmacology and clinical pharmacology.
synPHARM
SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.
Coronavirus
Our coronavirus information page has details of pharmcological strategies aimed at mitigating against COVID-19. The page also contains links to other useful resources and publications.
Please see our pre-print manuscript on "A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development"
Celebrating >20 years of Servier support
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