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Targets
- G protein-coupled receptors
- Ion channels
- Nuclear hormone receptors
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- Other protein targets
Ligands
- Approved drugs
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Resources
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IUPHAR/Servier Fibrosis Symposium
View and read the scientific presentations and report from the IUPHAR/Servier Fibrosis Symposium, held in November 2020.
What's new to Guide to PHARMACOLOGY
Coronavirus (Covid-19) - view our information page
Database version 2021.1 (18th Mar 21) - read release details in our blog
- GM-CSF added to coronavirus targets lists - a principal marker of severe COVID-19 immunopathology. New coronavirus linked ligands include ensovibep (MP0420), emovododstat & MK-7110.
- 220 ligands since last update, all curated with peptide or chemical structures
- New family of enzymes, Peptidyl-prolyl cis/trans isomerases (PPIases), has been added, including in particular those that are therapeutic targets.
- New download files: Ligands in SDF format and mapping file of GtoPdb ligand IDs to external ligand identifiers - see our downloads page.
- Ligand links to Reactome - both for reactions and drug entities
- Total curated anti-malarial ligands now stands at 105. There are now 37 anti-malarial targets, organised into subfamilies
Read our latest Database Report (Nov 2020) - download/view PDF
Latest News and Hot Topics in Pharmacology
Pharmacology of COVID-19
Themed issue in BJP
This themed issue includes IUPHAR Review 29: A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development, which made the cover of the issue.
The Concise Guide to PHARMACOLOGY 2019/20
Recent Publications
A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development. IUPHAR Review 29
Alexander SPH, Armstrong J, Davenport AP, Davies JA, Faccenda E, Harding SD, Levi-Schaffer F, Maguire JJ, Pawson AJ, Southan C, Spedding MJ (2020) Br J Pharmacol. 177(21):4942-4966. doi: 10.1111/bph.15094. 
Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28
Mariotti FR, Quatrini L, Munari E, Vacca P, Tumino N, Pietra G, Mingari MC, Moretta L (2020) Br J Pharmacol. 177(13):2889-2903. doi: 10.1111/bph.15081.
IUPHAR Review CXI: Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors
Gregory KJ, Goudet C (2021) Pharmacol Rev. 73: 521-569.
IUPHAR Review CX: Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function
Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D (2021) Pharmacol Rev. 73: 310-520.
Pharmacology Education
The IUPHAR Pharmacology Education Project is being developed by IUPHAR with support from ASPET as a learning resource for pharmacology and clinical pharmacology.
synPHARM
SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.
Coronavirus
Our coronavirus information page has details of pharmcological strategies aimed at mitigating against COVID-19. The page also contains links to other useful resources and publications.
Please see our pre-print manuscript on "A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development"
Celebrating >20 years of Servier support
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