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What's new to Guide to PHARMACOLOGY
Coronavirus (Covid-19) - view our information page
New database version 2020.3 (19 Jun 2020) - full details in our blog post
Our latest release includes:
- SARS-Cov-2 protein family which includes 13 members and is found under 'anti-infective targets' in our hierarchy
- An emerging oncology target, ACSS2, has been added plus two inhibitor probe compounds (example 265 and ADG-207).
- Updates have also been made to targets across 20+ different protein families
- Over 200 ligands are now marked as antibiotic and more than 100 of these have with links to Antibiotic DB
- Improvements have been made to ligand summary pages. Key information, such as synonyms, curator comments, links to activity graph and SMILES and InChI Keys have been prioritised.
Please read our latest Database Report (April 2020) - download/view PDF
Latest News and Hot Topics in Pharmacology
GtoMPdb
IUPHAR/MMV Guide to Malaria Pharmacology
Visit the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY portal
Launched in September 2019 to provide optimised access to GtoPdb data for the malaria research community
The Concise Guide to PHARMACOLOGY 2019/20
Recent Publications
A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development. IUPHAR Review 29
Alexander SPH, Armstrong J, Davenport AP, Davies JA, Faccenda E, Harding SD, Levi-Schaffer F, Maguire JJ, Pawson AJ, Southan C, Spedding MJ (2020) Br J Pharmacol. doi: 10.1111/bph.15094. 
Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28
Mariotti FR, Quatrini L, Munari E, et al. (2020) Br J Pharmacol. [online ahead of print]. doi: 10.1111/bph.15081.
IUPHAR review article on Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function
Leach K, Hannan FM, Josephs TM, Keller AN, Møller TC, Ward DT, Kallay E, Mason RS, Thakker RV, Riccardi D, Conigrave AD, Bräuner-Osborne H (2020) Pharmacol Rev. 72: 558-604.
IUPHAR review article on Structure and Pharmacology of the Apelin Receptor
Read C, Nyimanu D, Williams TL, Huggins DJ, Sulentic P, Macrae RGC, Yang P, Glen RC, Maguire JJ and Davenport AP (2019) Pharmacol Rev. 71: 764-502.
Pharmacology Education
The IUPHAR Pharmacology Education Project is being developed by IUPHAR with support from ASPET as a learning resource for pharmacology and clinical pharmacology.
synPHARM
SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.
Coronavirus
Our coronavirus information page has details of pharmcological strategies aimed at mitigating against COVID-19. The page also contains links to other useful resources and publications.
Please see our pre-print manuscript on "A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development"
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