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What's new to Guide to PHARMACOLOGY

Database version 2021.3 (2nd Sep 21) - read release details in our blog

  • Over 120 ligands added since last update, all curated with peptide or chemical structures.
  • Updated comments on over 170 ligands.
  • Our new beta homepage is available to try out!
  • HELM Notation is now provided for over 60 peptides
  • Total curated anti-malarial ligands now stands at 114, with 39 anti-malarial targets, organised into subfamilies.
  • New antibacterial ligand category, in continued collaboration with Antibiotic DB.
  • New download files: Ligands in SDF format and mapping file of GtoPdb ligand IDs to external ligand identifiers - see our downloads page.

Read our latest Database Report (Apr 2021) - download/view PDF

Coronavirus Information

Coronavirus (Covid-19) Information Page - view our information page which summarises ligands and drug targets relevant in pharmacological strategies to mitigate against COVID-19.

Latest News and Hot Topics in Pharmacology

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Pharmacology of COVID-19

Themed issue in BJP

BJP COVID-19 Cover

This themed issue includes IUPHAR Review 29: A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development, which made the cover of the issue.

The Concise Guide to PHARMACOLOGY 2021/22

Concise Guide to Pharmacology 2021/22

Access the table of contents go icon to follow link

The latest edition of The Concise Guide to PHARMACOLOGY is now online. Containing concise overviews of the key properties of over 1,800 pharmacological targets.

Please see the 5 minute introductory video on the Concise Guide:

Recent Publications

BJP journal cover

COVID-19 and the revival of passive immunization: Antibody therapy for inhibiting SARS-CoV-2 and preventing host cell infection: IUPHAR review: 31

Levi-Schaffer F, de Marco A (2021) Br J Pharmacol. Online ahead of print. doi: 10.1111/bph.15359. go icon to follow link

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30

Illes P, Müller CE, Jacobson KA, Grutter T, Nicke A, Fountain SJ, Kennedy C, Schmalzing G, Jarvis MF, Stojilkovic SS, King BF, Di Virgilio F. (2021) Br J Pharmacol. 178(3):489-514. doi: 10.1111/bph.15299. go icon to follow link

Pharm Rev journal cover

IUPHAR Review CXI: Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors

Gregory KJ, Goudet C (2021) Pharmacol Rev. 73: 521-569. go icon to follow link

IUPHAR Review CX: Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D (2021) Pharmacol Rev. 73: 310-520. go icon to follow link

Pharmacology Education

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The IUPHAR Pharmacology Education Project is being developed by IUPHAR with support from ASPET as a learning resource for pharmacology and clinical pharmacology.


synPHARM logo

SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.



The IUPHAR/BPS Guide to PHARMACOLOGY is one of the ELIXIR-UK node services.


Our coronavirus information page has details of pharmcological strategies aimed at mitigating against COVID-19. The page also contains links to other useful resources and publications.

Please see our pre-print manuscript on "A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development"

Celebrating >20 years of Servier support

Servier logo

Servier, a mid-size French Pharmaceutical company, has a long history in pharmacology, and has supported NC-IUPHAR for >20 years with unrestricted educational grants which have permitted the Paris meetings and thus progress of the database.