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Targets
- G protein-coupled receptors
- Ion channels
- Nuclear hormone receptors
- Kinases
- Catalytic receptors
- Transporters
- Enzymes
- Other protein targets
Ligands
- Approved drugs
- Synthetic organics
- Metabolites
- Natural products
- Endogenous peptides
- Other peptides
- Inorganics
- Antibodies
- Labelled ligands
Resources
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What's new to Guide to PHARMACOLOGY
Latest database release, version 2019.3 released 13th June 2019
- Release 2019.3 is the third release of the, please read full release details in our blog post
- The cereblon protein has been added, including quantitative data to three approved thalidomide type drugs
- Several 'new to GtoPdb' CRF-1 receptor antagonists
- Addition of nudix hydrolase 7 and the first reported covalent inhibitor NUDT7-COV-1
- The Antimalarial targets family and the Antimalarial ligands family have been updated, giving a total of 25 P. falciparum (3D7) targets and 65 ligands tagged as antimalarial in the database
- Expanded capture and display of Target Candidate Profiles in GtoMPdb
Latest News and Hot Topics in Pharmacology
GtoImmuPdb
CVR Onlife Interview
Prof. Alberto Mantovani and Prof. Michael Spedding introduce the IUPHAR Guide to IMMUNOPHARMACOLOGY in this CVR Onlife interview
The Concise Guide to PHARMACOLOGY 2017/18
A FREE publication snapshot created from the database summary pages.
Please see the 5 minute introductory video on the Concise Guide:
Recent Publications
IUPHAR review article on two-pore domain potassium channels
Gada K & Plant LD (2019) Br J Pharmacol. 176(2):256-266. doi: 10.1111/bph.14518. 
IUPHAR review article on the pharmacology of calcitonin/CGRP family of peptides
Hay DL, Garelja ML, Poyner DR, et al. (2018) Br J Pharmacol. 175(1):3-17. doi: 10.1111/bph.14075.
IUPHAR review article on GABAA Receptor Subtype- and Function-selective Ligands
Sieghart W & Savić MM. (2018) Pharmacol Rev. 70: 836-878.
IUPHAR review article on Somatostatin Receptors
Gunther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp H-J, Lupp A, Korbonits M, Castaño JP, Wester H-J, Culler M, Melmed S and Schulz S. (2018) Pharmacol Rev. 70: 763-835.
Pharmacology Education
The IUPHAR Pharmacology Education Project is being developed by IUPHAR with support from ASPET as a learning resource for pharmacology and clinical pharmacology.
synPHARM
SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.
Pharmacology 2018
The British Pharmacological Society's flagship annual meeting attracts over 1,100 scientists each year from across the world.
18-20 Oct 2018, London, UK
Register now: Early bird deadline is 18th Nov
Celebrating >20 years of Servier support
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