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Targets
- G protein-coupled receptors
- Ion channels
- Nuclear hormone receptors
- Kinases
- Catalytic receptors
- Transporters
- Enzymes
- Other protein targets
Ligands
- Approved drugs
- Synthetic organics
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- Natural products
- Endogenous peptides
- Other peptides
- Inorganics
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Resources
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What's new to Guide to PHARMACOLOGY
Latest database release, version 2019.2 released 28th March 2019
- Read full release details in our blog post
- This release, 2019.2, is the second of the year and includes updates focussed on preparation for the next edition of The Concise Guide to PHARMACOLOGY (2019/20), due out later this year
- Involves substantial reviews and updates by our expert subcommittees on the key properties of drug targets across all classes
- Over 200 new ligands added in this release, over 50% of which have quantitative interaction data
- Updated outlinks from GtoPdb targets to ChEMBL
- Updated endogenous/natural ligands curation
- IUPHAR/MMV Guide to Malaria PHARMACOLOGY beta-release (v2.0), includes new species data for P. yoelii
- Extended GtoMPdb search to cover parasite lifecycle stages and malaria species
Latest News and Hot Topics in Pharmacology
GtoImmuPdb
CVR Onlife Interview
Prof. Alberto Mantovani and Prof. Michael Spedding introduce the IUPHAR Guide to IMMUNOPHARMACOLOGY in this CVR Onlife interview
The Concise Guide to PHARMACOLOGY 2017/18
A FREE publication snapshot created from the database summary pages.
Please see the 5 minute introductory video on the Concise Guide:
Recent Publications
IUPHAR review article on two-pore domain potassium channels
Gada K & Plant LD (2019) Br J Pharmacol. 176(2):256-266. doi: 10.1111/bph.14518. 
IUPHAR review article on the pharmacology of calcitonin/CGRP family of peptides
Hay DL, Garelja ML, Poyner DR, et al. (2018) Br J Pharmacol. 175(1):3-17. doi: 10.1111/bph.14075.
IUPHAR review article on GABAA Receptor Subtype- and Function-selective Ligands
Sieghart W & Savić MM. (2018) Pharmacol Rev. 70: 836-878.
IUPHAR review article on Somatostatin Receptors
Gunther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp H-J, Lupp A, Korbonits M, Castaño JP, Wester H-J, Culler M, Melmed S and Schulz S. (2018) Pharmacol Rev. 70: 763-835.
Pharmacology Education
The IUPHAR Pharmacology Education Project is being developed by IUPHAR with support from ASPET as a learning resource for pharmacology and clinical pharmacology.
synPHARM
SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.
Pharmacology 2018
The British Pharmacological Society's flagship annual meeting attracts over 1,100 scientists each year from across the world.
18-20 Oct 2018, London, UK
Register now: Early bird deadline is 18th Nov
Celebrating >20 years of Servier support
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