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The IUPHAR/BPS Guide to PHARMACOLOGY complete ligand list

Non-peptidic, biogenic compounds derived from living organisms and their close synthetic derivatives.
Ligand name ID Synonyms
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852A Immunopharmacology Ligand 9025
A011 12776 compound 8d [Zhang et al., 2023]
A1120 PDB Ligand 8792 A 1120, compound 33 [PMID: 24835984]
A-1165442 12757 A1165442, compound 52 [PMID: 25100568]
A-119637 490 A 119637, A119637
A-123189 491 A 123189, A123189
A-1331852 11102 A 1331852, A1331852
A134974 5130 A 134974, A-134974
A192621 1009 A 192621, A-192621
A-196 PDB Ligand 8949
A286982 Immunopharmacology Ligand 6592 A 286982, A-286982
A-304121 1258 A 304121, A304121
A317491 PDB Ligand 4115 A 317491, A-317491
A-317567 4116 A 317567, A317567
A-317920 1216 A 317920, A317920
A331440 4023 A 331440, A-331440
A-349821 1217 A 349821, A-349,821, A349821
A-366 PDB Ligand 8238 A 366, A366
A-381393 8441 A 381393, A-381,393
A-395 9525
A412997 3301 A-412,997, A-412997
A425619 4117 A 425619, A-425619
A438079 Immunopharmacology Ligand 4118 A 438079, A-438079
A-443654 PDB Ligand 8204 A 443654, A443654
A-582941 3995 A 582941, A582941
A61603 480 A 61603, A-61603
A-674563 PDB Ligand 5655 A 674563, A674563
A68930 6077 A 68930, A 70108, A 70360, A-68930, A-70108, A-70360, A70108, A70360
A-71378 894 A 71378, A71378
A-71623 858 A 71623, A71623, L-phenylalaninamide
A-71915 4856 A 71915, A71915, H-3048
A740003 4119 A 740003, A-740003
A-769662 PDB Ligand 10069 A769662
A77636 9637 A-77636
A778317 4120 A 778317, A-778317
A-794278 6354 A 794278, A794278, compound 1ac [PMID: 16279797]
A-794282 6211 A 794282, A794282, compound 1n [PMID: 16279797]
A-803467 PDB Ligand 5734 A 803467, A803467
A804598 4121 A 804598, A-804598
A839977 4122 A 839977, A-839977
A-841720 3953 A 841720, A841720
A-850002 6355 A 850002, A850002, compound 28b [PMID: 16279797]
A-85380 5460 A 85380, A85380
A-867744 3986 A 867744, A867744
A8Δ71-73 5780
A-908292 10669
A-935142 7661 A 935142, A935142
A947 12308
A-967079 6280 A 967079, A967079
A-971432 9496
[3H]A317491 Ligand is labelled Ligand is radioactive PDB Ligand 5407 [3H]A 317491, [3H]A-317491
[3H]A-585539 Ligand is labelled Ligand is radioactive 3974
[3H]A778317 Ligand is labelled Ligand is radioactive 4076
[3H]A804598 Ligand is labelled Ligand is radioactive 5408 [3H]A 804598
[3H]A81988 Ligand is labelled Ligand is radioactive 3938 [3H]-A81988
A2315A 10846
AAE-M-PBP-amine 8289 acetylaminoethyl-methyl-phenylbutoxyphenyl-amine
AB928 PDB Ligand Immunopharmacology Ligand 11154 AB-928
abacavir Approved drug PDB Ligand 11152 ABC, 1592U89, Ziagen®
abagovomab 8265 ACA125, MEN-2234
abaloparatide Approved drug 8299 BA058, Tymlos®
abarelix Approved drug 1188 Plenaxis®, PPI 149, R 3827
abatacept Approved drug Immunopharmacology Ligand 6891 BMS-188667, CTLA4-IgG4m, Orencia®, RG-1046, RG-2077
Abbott 14c 5871 2,4-diaminopyrimidine-based antagonist, 14c
ABBV-154 12918 ADC11
ABBV-318 12002 ABBV318, compound 73 [PMID: 35436748]
ABBV-3221 10577 ABBV/GLPG-3221, compound 19 [PMID: 31749908]
ABBV-3373 Immunopharmacology Ligand 12917 ADC 122
ABBV-744 PDB Ligand 10730 ABBV 744, ABBV744
ABBV-CLS-484 PDB Ligand 11968 AC484
abciximab Approved drug 6584 7E3 antibody, antiGPIIBIIIa, C7E3, ReoPro®
ABD-1970 11816 ABD1970
abediterol Immunopharmacology Ligand 9326 LAS-100977
abelacimab 12417 MAA-868, MAA868, NVS250519
abemaciclib Approved drug PDB Ligand 7382 CS-1230, HY-16297A, LY 2835219, LY-2835219 , LY2835219, Verzenio®, Verzenios®
abexinostat 8366 CRA-024781, CRA-24781, PCI-24781
AbGn-168H Immunopharmacology Ligand 10013 AbGn-168, neihulizumab
A(4-24)(B7-24)H2 8346 A(4-24)(B7-24)H2 relaxin
A(4-24)(B7-24)H2 chain A 8347 A(4-24)H2 relaxin
A(4-24)(B7-24)H2 chain B 8348 (B7-24)H2 relaxin
abicipar pegol 8371 AGN-150998, MP0112
abimtrelvir 11870
abiraterone PDB Ligand 6745
abiraterone acetate Approved drug 9288 Yonsa®, Zytiga®
abivertinib 10044 AC0010, AC0010MA, avitinib (superceded INN), FUJOVEE®
ABL127 8608 ABL 127, ABL-127
AB-MECA 416
[125I]AB-MECA Ligand is labelled Ligand is radioactive 436 [125I]-AB-MECA, [125I]5-[6-[(4-aminophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyl-oxolane-2-carboxamide, [125I]N(6)-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide
AB-NECA 434 aminobenzyl-5'-N-ethylcarboxamidoadenosine
abnormal cannabidiol PDB Ligand 5526 Abn-CBD, CAY10429
[125I]ABOPX Ligand is labelled Ligand is radioactive 452 [125I]3-(3,4-aminobenzyl)-8-(4-oxyacetate)phenyl-1-propyl-xanthine
abrezekimab Immunopharmacology Ligand 9806 CDP7766, UCB-4144, UCB4144, VR-942
abrilumab Immunopharmacology Ligand 11531 AMG 181, AMG-181, MEDI-7183, MEDI7183
abrocitinib Approved drug PDB Ligand Immunopharmacology Ligand 9991 Cibinqo®, compound 25 [PMID: 29298069], PF-04965842, PF04965842
ABS-201 5308 ABS 201, ABS201, HPI-201, HPI201, KK13
ABS-212 5307 ABS 212, ABS212
abscisic acid Immunopharmacology Ligand 10362 (+/-)-(cis,trans)-abscisic acid, (+/-)-Abscisic acid, (RS)-Abscisic acid, ABA
absinthin 12458 (+)-absinthin, absynthin
ABT-239 1218 ABT 239, ABT239
ABT-288 6927 ABT 288, ABT288
ABT-299 1849 ABT 299, ABT299
ABT-384 7357 ABT 384, ABT384
ABT-491 PDB Ligand 1850 ABT 491, ABT491
ABT-639 7721 ABT 639, ABT639
ABT-670 8439 ABT 670, ABT670, compound 6b [PMID 17149874]
ABT702 5131 ABT 702, ABT-702
ABT-737 PDB Ligand Immunopharmacology Ligand 8320 ABT 737, ABT737, compound 2 [PMID 17256834]
ABX-002 12973 ABX002, compound 1 [WO2022236133A1]
ABX-1431 10062 ABX1431, compound 28 [PMID: 30067909], compound 9aq [WO2013103973A1], example 82 [WO2013103973A1]
Abz-Ser-Pro-Tyr(NO2)-OH 5132 o-aminobenzoyl-Ser-Pro-Tyr(NO2)-OH, TBC5182
AC-178,335 2065 AC 178335
AC-186 8897 AC 186
AC187 689 AC 187, AC-187, acetyl-(Asn30,Tyr32)-calcitonin8-32, salmon calcitonin (8-32) reduced
AC1903 10290 AC-1903
AC-260584 334 AC 260584, AC260584
AC261066 4054 AC 261066, AC-261066
AC262620 4017 AC 262620, AC-262620
AC262970 4018 AC 262970, AC-262970
AC263093 4020 AC 263093, AC-263093
AC264613 9460 AC-264613, compound 3 [PMID: 18720984]
AC265347 3947 AC 265347, AC-265347
AC-42 289 AC 42, AC42
AC430 Immunopharmacology Ligand 9177 AC-430
AC45594 5422 4-(heptyloxy)benzolol, 4-heptoxyphenol
AC-55541 9456 AC55541
AC55649 4055 AC 55649, AC-55649
AC710 8095 AC 710, AC-710
AC-7954 2151 AC 7954, AC7954
AC-90179 174 AC 90179, AC90179
AC-98170 9457 AC98170
ACAA 2443 ACA
acadesine 5133 AICA-riboside, AR-100, SCH-900395
acalabrutinib Approved drug PDB Ligand Immunopharmacology Ligand 8912 ACP-196, Calquence®, Example 6 [US20140155385 A1]
acalisib 10096 CAL-120, GS-9820
acamprosate Approved drug 7106 Campral®
acarbose Approved drug PDB Ligand 6791 BAY-G 5421, BAY-G-5421, Glucobay®, Precose®
7ACC2 PDB Ligand 8818 compound 19 [PMID: 24095010]
Ac-c[Cys-Glu-His-D-Phe-Arg-Trp-D-Cys]-Pro-Pro-Lys-Asp-NH2 1342
Ac-[13C,15N]PGP Ligand is labelled Ligand is radioactive 12599
Ac-DEVD-CHO 6527
[Ac-D-2Nal1,D4CPA2,D-3Pal3,6,Leu8, D-Ala10]GnRH-II 5583
ACDPP 3388
acebilustat 11984 CTX-4430, CTX4430
acebutolol Approved drug 7107 IL-17803A, Sectral®
(-)-aceclidine 288 R-(-)-aceclidine
(+)-aceclidine 286 S-(+)-aceclidine
acelarin 7389 NUC-1031
acenocoumarol Approved drug 9015 Sinthrome®, Sintrom®
acesulfame PDB Ligand 12460 acetosulfam
ACET PDB Ligand 4123
acetaldehyde PDB Ligand 6277 acetic aldehyde, ethanal, ethyl aldehyde, NSC 7594
acetamide PDB Ligand 4661 ethanamide, methylformamide
acetazolamide Approved drug PDB Ligand 6792 Diamox®
acetic acid PDB Ligand 1058 acetate, ethanoic acid
acetoacetic acid 4522 acetoacetate, diacetic acid
acetoacetyl CoA PDB Ligand 3039 3-acetoacetyl-CoA, acetoacetyl coenzyme A, acetoacetyl-CoA, acetoacetyl-coenzyme a
acetohexamide Approved drug 6793 Dymelor®
1'-acetoxychavicol acetate 6298
acetylcholine PDB Ligand 294 ACh, E1001, O-acetylcholine
[3H]acetylcholine Ligand is labelled Ligand is radioactive PDB Ligand 8593
acetyl CoA PDB Ligand 3038 acetyl coenzyme A, acetyl-CoA, acetylCoA, S-acetyl coenzyme A
[14C]acetylCoA Ligand is labelled Ligand is radioactive 4541 [14C]-acetylCoA
acetylcysteine Approved drug PDB Ligand 10945 Ilube® (eye drops), N-A-C Sustain®, N-Acetyl-cysteine, N-Acetyl-L-cysteine, NAC, Parvolex®
acetyldigitoxin Approved drug 6794 acetyldiginatin, Acylanid®, alpha-acetyldigitoxin
acetyl-L-carnitine 4520 (-)-Acetylcarnitine, ALCAR, L-Acetylcarnitine, Levocarnitine acetyl, O-Acetyl-L-carnitine
acetyl-podocarpic dimer 2753 APD, acetyl podocarpic acid anhydride
Ac-GRP-(20-26)-methylester 625 N-acetyl-GRP-(20-26)-ethylester
AChE reactivator 2 10074
[Ac-His1]PACAP-27 2263 [Ac-His1]pituitary adenylate cyclase activating polypeptide-27
[125I][Ac-His1]PACAP-27 Ligand is labelled Ligand is radioactive 2260 [125I]-[Ac-His1]pituitary adenylate cyclase activating polypeptide-27
Ac-hMCH-(6-16)-NH2 1290 hAc-MCH(6-16)-NH2, human Ac-MCH6-16-NH2
aciclovir Approved drug PDB Ligand 4829 acyclovir, Zovirax®
acifran 1595 AY-25712, D02753, reductol
A(Δ10/15C)INSL3 8332
acipimox Approved drug 1596 Olbetam®
acitretin Approved drug 7598 Ro-101670000, Soriatane®
acivicin PDB Ligand 11402 AT-125, AT125, U 42,126, U-42,126, U-42126
aclerastide 8300 DSC-127, DSC127, NorLeu3-A(1-7)
aclidinium Approved drug 7449 LAS W-330, LAS-34273, Tudorza Pressair®
acloproxalap 12097 Compound 5 [WO2020223685A1]
Ac-Lys-[MeAla6,Leu8,des-Arg9]bradykinin 651 N-acetylated-[Lys,MeAla6,Leu8,des-Arg9]bradykinin, Ac-[MeAla6,Leu8,des-Arg9]kallidin
aconitine 2617
acorafloxacin 10753 avarofloxacin (former name), JNJ-Q2, JNJQ2
AcPhe-Orn-Pro-D-Cha-Trp-Arg 3853 AcF[OP-D-Cha-Wr]
Ac-Phe-Trp-Ala-His(τBZL)-Nip-Gly-Arg-NH2 6191
[35S]ACPPB Ligand is labelled Ligand is radioactive 4584 [35S]-ACPPB
ACPT-I 1408 1-aminocyclopentane-1,3,4-tricarboxylic acid
ACQ090 2076 NVP ACQ090
Ac-RHYPLWR 8380
acrizanib 12782 compound 35 [PMID: 29400470], LHA-510, LHA510
acrolein 2418 propenal
acrylamide PDB Ligand 4553
4-acryloylphenol 8841 compound 6
Ac-RYYRIK-NH2 1679
Ac-RYYRWK-NH2 1680
Ac-SDKP Immunopharmacology Ligand 10060 goralatide, seraspenide
A(C10/15S)INSL3 8331
ACT-1014-6470 Immunopharmacology Ligand 12326 example 172 [WO2019137927A1], Ic-58
ACT-335827 9122 ACT 335827, compound 9 [PMID: 23589487]
ACT-389949 Immunopharmacology Ligand 9511
ACT-451840 Antimalarial Ligand 10022 ACT451840, Actelion-451840
ACT-462206 PDB Ligand 9303 compound 24 [PMID: 25147058]
ACT-660602 Immunopharmacology Ligand 12207 ACT660602, compound 9j [PMID: 35947786]
ACT-709478 12647 ACT709478, compound 66b [PMID: 29116786], NBI-827104, NBI827104
ACT-777991 Immunopharmacology Ligand 12584 ACT777991, compound 8a [PMID: 36883854]
ACTH  {Sp: Human} Approved drug Immunopharmacology Ligand 3633 Acthar®, adrenocorticotropic hormone (1-39), corticotropin
ACTH  {Sp: Mouse, Rat} 1331 ACTH (1-39), adrenocorticotrophin, adrenocorticotropic hormone (1-39), corticotropin
ACTH-(11-24) 1332 ACTH (11-24), adrenocorticotropic hormone (11-24)
ACTH-(1-24) 1330 ACTH (1-24), adrenocorticotropic hormone (1-24)
[125I]ACTH-(1-24) Ligand is labelled Ligand is radioactive 3767 [125I]-ACTH(1-24), [125I]-adrenocorticotropin(1-24)
activin A  {Sp: Human} 4857
activin AB  {Sp: Human} 4858
activin B  {Sp: Human} 4859
[Ac-Tyr1, D-Arg2]GHRH-(1-29)-NH2 (human) 1125
acumapimod Immunopharmacology Ligand 9203 BCT 197, BCT-197, BCT197, compound A [WO2013139809]
Ac-VEID-CHO 8566 acetyl-Val-Ile-Asp-aldehyde
ACY-738 11120 example 73 [WO2012068109A2]
AD-5061 2663 AD 5061, AD 7057, AD-7057, AD5061, AD7057
AD5075 2701 AD 5075, AD-5075
[3H]AD5075 Ligand is labelled Ligand is radioactive 2702 [3H]-AD5075
adagrasib Approved drug PDB Ligand 10888 compound 20 [PMID: 32250617], Krazati®, MRTX-849, MRTX849
adalimumab Approved drug Immunopharmacology Ligand 4860 D2E7, Humira®
adapalene Approved drug 5429 Differin®
adaptavir 11692 D-Ala-peptide T-amide, DAPTA
adavosertib PDB Ligand 7702 AZD 1775, AZD-1775, AZD1775, MK-1775, MK1775
adenine PDB Ligand 4788
adenophostin A 4124
adenosine Approved drug PDB Ligand 2844 Adenocard®, Adenoscan®
adenosine-3'-5'-bisphosphate PDB Ligand 1718 adenosine 3',5'-bisphosphate, adenosine 3',5'-diphosphate
adenosine 5'-monophosphate PDB Ligand 2455 AMP, 5'-AMP, adenosine monophosphate
ADG-207 11068
adiponectin  {Sp: Human} 3726 flAdipo
ADL5747 9003 ADL 5747, ADL-5747, compound 36 [PMID: 19694468]
ADL5859 9004 ADL 5859, ADL-5859, compound 20 [PMID: 18788723]
adomeglivant Approved drug 9479 LY2409021
ADP PDB Ligand 1712 adenosine diphosphate
ADP ribose 2444
ADP-ribosylation factor 1  {Sp: Human} 5305 Arf1, ARF-1
ADPβS PDB Ligand 1755 adenosine 5'-O-(2-thiodiphosphate), ADPbetaS
[35S]ADPβS Ligand is labelled Ligand is radioactive 3408
(-)-adrenaline Approved drug PDB Ligand Immunopharmacology Ligand 479 adrenalin, Auvi-Q®, Epipen®, l-adrenaline, L-epinephrine, levoepinephrine
(+)-adrenaline PDB Ligand 4450 (S)-(+)-adrenaline, (S)-adrenaline
(±)-adrenaline 509 adrenaline, epinephrine
adrenomedullin  {Sp: Human} Immunopharmacology Ligand 683 AM
adrenomedullin  {Sp: Mouse} 3589 AM, mouse adrenomedullin
adrenomedullin  {Sp: Rat} 697 AM
adrenomedullin 2/intermedin  {Sp: Human} 684 AM2/IMD
adrenomedullin 2/intermedin  {Sp: Mouse} 3590
adrenomedullin 2/intermedin  {Sp: Rat} 3591
adriforant Immunopharmacology Ligand 8985 PF 3893787, PF-03893787, ZPL-389, ZPL-3893787, ZPL389, ZPL3893787
adrixetinib 12375 example 7 [US2021163448A1]
adropin  {Sp: Human} 9573
(+)-ADTN 932 (+)-ADTN (aminotetralin-6,7-diol)
aducanumab Approved drug 8325 aducanumab-avwa, Aduhelm®, BART, BIIB-037, BIIB037
ADU-S100 Immunopharmacology Ligand 10192 dithio-(Rp,Rp)-[cyclic[A(2',5')pA(3',5')p]], MIW815, ML RR-S2 CDA, S100
ADX-47273 1420 ADX 47273, ADX47273
ADX71743 6217 ADX 71743, ADX-71743
ADX88178 PDB Ligand 6238 ADX 88178, ADX-88178
AE9C90CB 8586
AEE788 PDB Ligand 7643 AEE 788, NVP-AEE788
AF12198 Immunopharmacology Ligand 4861 AF 12198, AF-12198
AF353 4125 AF 353, AF-353
AF-906 9538 compound 128 [PMID: 26686393], Ro-51
afabicin 10754 AFN-1720, Debio 1450, Debio1450
A(4-24)(F23A)H2 8349
afamelanotide Approved drug 1324 α-NDP-MSH, [Nle4,dPhe7]α-MSH, CUV-1647, CUV1647, NDP-MSH, Scenesse®
afatinib Approved drug PDB Ligand 5667 BIBW2992, Gilotrif®
AFD(R) 2937
AFDX384 3264 AF-DX 384, AFDX-384
[3H]AF DX-384 Ligand is labelled Ligand is radioactive 368 [3H]AF-DX 384
afegostat PDB Ligand 7410 IFM, iso-fagomine, isofagomine
aficamten 11524 CK-274, CK-3773274, CK3773274
aflibercept Approved drug 6786 AVE0005, Eylea®, VEGF Trap, Zaltrap®, ziv-aflibercept
AFM13 Immunopharmacology Ligand 10067 AFM 13, AFM-13
AFP-07 1962 AFP 07, AFP07
AFT-II 2613 neurotoxin-2, Toxin AFII, Toxin AFT-II
afuresertib 7890 GSK 2110183, GSK-2110183, GSK2110183
AG-09/1 5833 AG-09/1 [benzimidazole derivative], ST024252
AG 1024 5912 AG-1024, AG1024, tyrphostin AG 1024
AG-11/03 5832 AG-11/03 [benzimidazole derivative], STK220090
AG 112 5913 AG-112, AG112, tyrphostin A48, tyrphostin AG 112
AG-122018 11398 compound 18 [PMID: 25091930]
AG 1295 5914 AG-1295, AG1295
AG 1296 5915 AG-1296, AG1296, tyrphostin AG-1296
AG-14 5835 AG 14, AG14
AG14361