salidroside [Ligand Id: 13729] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL465208 (Salidroside)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of COX1 B 4.14 pIC50 72000 nM IC50 J Nat Prod (2005) 68: 985-991 [PMID:16038536]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL Competitive inhibition of human recombinant MAO-B expressed in baculovirus infected BTI cells assessed as inhibition of 4-hydroxyquinoline formation using varying concentration of kynuramine as substrate preincubated with enzyme for 10 mins followed by addition of substrate and measured after 15 mins by Lineweaver-Burk plot analysis B 6.04 pKi 920 nM Ki Eur J Med Chem (2021) 209: 112935-112935 [PMID:33097301]
GtoPdb - - 6.04 pKi 920 nM Ki Eur J Med Chem (2021) 209: 112935 [PMID:33097301]
ChEMBL Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI cells assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate preincubated with enzyme for 10 mins followed by addition of substrate and measured after 15 mins by fluorescence spectrophotometry B 6.09 pIC50 810 nM IC50 Eur J Med Chem (2021) 209: 112935-112935 [PMID:33097301]
Ribonuclease HI in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770039] [UniProtKB: P0A7Y4]
ChEMBL Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay B 4.7 pIC50 >20000 nM IC50 Bioorg Med Chem Lett (2011) 21: 2840-2844 [PMID:21489793]
ChEMBL Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay B 4.7 pIC50 >20000 nM IC50 Bioorg Med Chem Lett (2011) 21: 2840-2844 [PMID:21489793]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]