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The IUPHAR/BPS Guide to PHARMACOLOGY complete ligand list

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All ligands in the database which are currently, or have been in the past, approved for human clinical use by a regulatory agency.

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Ligand name ID Synonyms
A Back to top
abacavir Approved drug PDB Ligand 11152 ABC, 1592U89, Ziagen®
abaloparatide Approved drug 8299 BA058, Tymlos®
abarelix Approved drug 1188 Plenaxis®, PPI 149, R 3827
abatacept Approved drug Immunopharmacology Ligand 6891 BMS-188667, CTLA4-IgG4m, Orencia®, RG-1046, RG-2077
abciximab Approved drug 6584 7E3 antibody, antiGPIIBIIIa, C7E3, ReoPro®
abemaciclib Approved drug PDB Ligand 7382 CS-1230, HY-16297A, LY 2835219, LY-2835219 , LY2835219, Verzenio®, Verzenios®
abiraterone acetate Approved drug 9288 Yonsa®, Zytiga®
abrocitinib Approved drug PDB Ligand Immunopharmacology Ligand 9991 Cibinqo®, compound 25 [PMID: 29298069], PF-04965842, PF04965842
acalabrutinib Approved drug PDB Ligand Immunopharmacology Ligand 8912 ACP-196, Calquence®, Example 6 [US20140155385 A1]
acamprosate Approved drug 7106 Campral®
acarbose Approved drug PDB Ligand 6791 BAY-G 5421, BAY-G-5421, Glucobay®, Precose®
acebutolol Approved drug 7107 IL-17803A, Sectral®
acenocoumarol Approved drug 9015 Sinthrome®, Sintrom®
acetazolamide Approved drug PDB Ligand 6792 Diamox®
acetohexamide Approved drug 6793 Dymelor®
acetylcysteine Approved drug PDB Ligand 10945 Ilube® (eye drops), N-A-C Sustain®, N-Acetyl-cysteine, N-Acetyl-L-cysteine, NAC, Parvolex®
acetyldigitoxin Approved drug 6794 acetyldiginatin, Acylanid®, alpha-acetyldigitoxin
aciclovir Approved drug PDB Ligand 4829 acyclovir, Zovirax®
acipimox Approved drug 1596 Olbetam®
acitretin Approved drug 7598 Ro-101670000, Soriatane®
aclidinium Approved drug 7449 LAS W-330, LAS-34273, Tudorza Pressair®
ACTH  {Sp: Human} Approved drug Immunopharmacology Ligand 3633 Acthar®, adrenocorticotropic hormone (1-39), corticotropin
adagrasib Approved drug PDB Ligand 10888 compound 20 [PMID: 32250617], Krazati®, MRTX-849, MRTX849
adalimumab Approved drug Immunopharmacology Ligand 4860 D2E7, Humira®
adapalene Approved drug 5429 Differin®
adenosine Approved drug PDB Ligand 2844 Adenocard®, Adenoscan®
adomeglivant Approved drug 9479 LY2409021
(-)-adrenaline Approved drug PDB Ligand Immunopharmacology Ligand 479 adrenalin, Auvi-Q®, Epipen®, l-adrenaline, L-epinephrine, levoepinephrine
aducanumab Approved drug 8325 aducanumab-avwa, Aduhelm®, BART, BIIB-037, BIIB037
afamelanotide Approved drug 1324 α-NDP-MSH, [Nle4,dPhe7]α-MSH, CUV-1647, CUV1647, NDP-MSH, Scenesse®
afatinib Approved drug PDB Ligand 5667 BIBW2992, Gilotrif®
aflibercept Approved drug 6786 AVE0005, Eylea®, VEGF Trap, Zaltrap®, ziv-aflibercept
agomelatine Approved drug PDB Ligand 198 S20098, Thymanax®, Valdoxan®
ajmalicine Approved drug PDB Ligand 8746 delta-yohimbine, raubasine, rauvasan, rauwolfia alkaloid
albiglutide Approved drug 7386 Eperzan®, GSK716155, Tanzeum®
alcaftadine Approved drug Immunopharmacology Ligand 7587 Lastacaft®, R-89674
alectinib Approved drug PDB Ligand 7739 AF802, Alecensa®, CH5424802
alefacept Approved drug Immunopharmacology Ligand 6787 Amevive®, BG 9273, BG 9712, BG-9273, BG-9712, Lfa3Tip
alemtuzumab Approved drug Immunopharmacology Ligand 6770 campath 1H, Campath®, campath-1H, Lemtrada®
alendronate Approved drug PDB Ligand 3141 ABDP, BPH 1, Fosamax®, MK-217
alfentanil Approved drug 7108 Alfenta®, R-39209, Rapifen®
alfuzosin Approved drug 7109 SL-77499-10, SL-7749910, Uroxatral®
alglucosidase alfa Approved drug 7561 Lumizyme®, Myozyme®, rhGAA
alimemazine Approved drug Immunopharmacology Ligand 7237 Nedeltran®, trimeprazine
alirocumab Approved drug 6744 Praluent®, REGN727, SAR-236553, SAR236553
aliskiren Approved drug PDB Ligand 4812 CGP-060536B, SPP100, Tekturna®
alitretinoin Approved drug PDB Ligand 2645 9-cis-retinoic acid, Panretin®, Toctino®
alizapride Approved drug 11141 Limican®, Litican®, Nausilex®, Plitican®, Superan®, Vergentan®
allopurinol Approved drug 6795 Aloprim®, BW-56-158, BW-56158, Zyloprim®
almonertinib Approved drug 11136 Ameile, Egfr T790M inhibitor HS-10296, example 26 [WO2016054987A1], HS10296
almotriptan Approved drug 7110 Almogran®, Axert®, LAS-31416, PNU-180638E
alogliptin Approved drug PDB Ligand 6319 Nesina®, SYR-322, Vipidia®
alosetron Approved drug PDB Ligand 2296 GR68755, Lotronex®
alpelisib Approved drug PDB Ligand 7955 BYL 719, BYL-719, NVP-BYL719, Piqray®, Vijoice®
alpha-methyltyrosine Approved drug 6956 Demser®, metyrosine, MK-781
alpha1-proteinase inhibitor Approved drug 7487 A1AT, A1PI, alpha 1-antitrypsin, Aralast®, Prolastin®, serum trypsin inhibitor
alprazolam Approved drug PDB Ligand 7111 Niravam®, U-31889, Xanax®
alprenolol Approved drug 563 Atenenol®
AlprolixTM Approved drug 7373
altretamine Approved drug 7112 Hexalen®
alvimopan Approved drug PDB Ligand 7471 ADL 8-2698, Entereg®
amantadine Approved drug 4128 ADS-5102, Gocovri®, Symadine®, Symmetrel®
ambrisentan Approved drug 3951 Letairis®
ambroxol Approved drug 10692
amcinonide Approved drug Immunopharmacology Ligand 7060 CL-34699, Cyclocort®
amfenac Approved drug 7565 AHR-5850D, Fenazox® (Japan)
amifampridine Approved drug PDB Ligand 8032 3,4-DAP, 3,4-diaminopyridine, Firdapse®, Ruzurgi®, Zenas®
amikacin Approved drug PDB Ligand 10894 Amikin®, AMK, Arikayce liposomal®, BB-K8
amiloride Approved drug PDB Ligand 2421 amiloride HCl, Midamor®
6-aminocaproic acid Approved drug PDB Ligand 6574 ε-aminocaproic acid, Amicar®, EACA
aminoglutethimide Approved drug 7054 Cytadren®
aminohippuric acid Approved drug PDB Ligand 4810 PAH, Aminohippurate Sodium®, p-aminohippurate, p-aminohippuric acid, PAH
5-aminolevulinic acid Approved drug PDB Ligand 4784 5-aminolevulinate, Ameluz®, D-aminolevulinic acid, Gliolan®, Levulan®
amiodarone Approved drug PDB Ligand 2566 amiodarone hydrochloride, Cordarone®
amisulpride Approved drug 963 (±)-amisulpride, Barhemsys®
amitriptyline Approved drug PDB Ligand 200 amitryptiline, Elavil®, Endep®
amivantamab Approved drug 10505 amivantamab-vmjw, JNJ-61186372, JNJ-6372, JNJ61186372, Rybrevant®
amlexanox Approved drug PDB Ligand Immunopharmacology Ligand 7113 AA-673, Amlexanox®, Aphthasol®, CHX-3673
amlodipine Approved drug 6981 amlodipine besylate, amlodipine maleate, Copalia® (amlodipine + valsartan), Katerzia® (amlodipine oral suspension, 1 mg/mL), Norvasc®, UK-4834011
amodiaquine Approved drug PDB Ligand Antimalarial Ligand 10018 Alphaquine®, Amdaquine®, Amoquin®, Camoquin®, Flavoquine®
amoxapine Approved drug 201 amoxipine, Asendin®
amoxicillin Approved drug 10895 Amoxil®, BRL-2333, co-amoxiclav (amoxicillin + clavulanic acid), Moxatag®, NSC-277174, Trimox®
amphetamine Approved drug 4804 (±)-amphetamine, Amphetamine Sulfate®, DL-amphetamine
ampicillin Approved drug PDB Ligand 10896 aminobenzylpenicillin, KS-R1, Penbritin®, Polycillin, Principen®
amprenavir Approved drug PDB Ligand 12681 Agenerase®, AMV, Prozei®, VX-478, VX478
anagliptin Approved drug PDB Ligand 11582 compound 4a [PMID: 22019046], CWP-403, SK-0403, SK0403, Suiny®
anagrelide Approved drug PDB Ligand 7114 Agrylin®, BL-4162a, Xagrid®
anakinra Approved drug Immunopharmacology Ligand 6972 antril, Kineret®
anastrozole Approved drug 5137 Arimidex®
andexanet alfa Approved drug 7576 Andexxa®, coagulation factor Xa (recombinant), inactivated-zhzo, Ondexxya®, PRT064445, PRT4445, r-antidote
angiotensin II  {Sp: Human, Mouse, Rat} Approved drug 2504 ang II, Giapreza®
anifrolumab Approved drug Immunopharmacology Ligand 8258 anifrolumab-fnia, MDX-1333, MEDI-546, Saphnelo®
anileridine Approved drug 7115 Leritine®
aniracetam Approved drug PDB Ligand 4133
anisindione Approved drug 6960 Miradon®
antazoline Approved drug 7116
apalutamide Approved drug 9043 ARN-509, ARN509, Erleada®, JNJ-56021927
apixaban Approved drug PDB Ligand 6390 BMS-562247, Eliquis®
apomorphine Approved drug PDB Ligand 33 Apokyn®, Ixense®, Kynmobi® (sublingual film), Uprima®
apraclonidine Approved drug 7117 AL-02145, Iopidine®
apremilast Approved drug PDB Ligand Immunopharmacology Ligand 7372 CC-10004, Otezla®
aprepitant Approved drug PDB Ligand 3490 Aponvie®, Emend®
aprotinin  {Sp: Bovine} Approved drug 6570 basic protease inhibitor (BPI), BPTI, pancreatic trypsin inhibitor, Trasylol®
aranidipine Approved drug 11744 MPC-1304, MPC1304, Sapresta®
arbekacin Approved drug PDB Ligand 7345 arbekacin sulfate, habekacin, ME1100, NPC-14
arformoterol Approved drug PDB Ligand Immunopharmacology Ligand 7479 Brovana®, YM-08316
argatroban Approved drug 6385 DK-7419, GN-1600, Gn1600, MCI-9038, MD-805
aripiprazole Approved drug PDB Ligand 34 Abilify®, Aripiprex®, Aristada® (aripiprazole lauroxil), OPC 14597, OPC-14597
artemether Approved drug PDB Ligand Antimalarial Ligand 9955 β-artemether, beta-artemether
artenimol Approved drug Antimalarial Ligand 9957 DHA, dihydroartemisinin, GNF-Pf-5634
artesunate Approved drug PDB Ligand Antimalarial Ligand 9956
asciminib Approved drug PDB Ligand 8962 ABL-001, ABL001, compound 1 [PMID: 30137981], Example 9, Scemblix®
asenapine Approved drug 22 ORG-5222, ORG5222, Saphris®, Secuado® (transdermal asenapine), Sycrest®
aspirin Approved drug PDB Ligand Immunopharmacology Ligand 4139 Acetophen®, acetylsalicylic acid, Aspirin®
aspoxicillin Approved drug 12293 Doyle®, TA-058
astemizole Approved drug PDB Ligand 2603 Hismanal®
asunaprevir Approved drug PDB Ligand 10882 BMS-650032, BMS650032, compound 24 [PMID: 24564672], Sunvepra™
ataluren Approved drug PDB Ligand 7341 PTC124
atazanavir Approved drug PDB Ligand 11138 ATV, BMS-232632, CGP 73547, latazanavir, Reyataz®, zrivada
atenolol Approved drug 548 Myocord®, Normiten®, Tenormin®
atezolizumab Approved drug Immunopharmacology Ligand 7990 MPDL3280A, Tecentriq®
atogepant Approved drug 9730 AGN-241689, Aquipta®, example 4 [US20120122911], MK-8031, Qulipta®
atomoxetine Approved drug 7118 LY-139603, Strattera®
atorvastatin Approved drug PDB Ligand 2949 Lipitor®
atosiban Approved drug 2213 Antocin®, d[D-Tyr(Et)2,Thr4,Orn8]vasotocin, d[D-Tyr(Et)2,Thr4]OVT, ORF22164, RWJ 22164, Tractocile®
atovaquone Approved drug PDB Ligand Antimalarial Ligand 9695 566C80, Mepron®, Wellvone®
atracurium Approved drug Immunopharmacology Ligand 9537 atracurium besilate, atracurium dibesylate, BW 33A, Tracrium®
atropine Approved drug 320 Atropen®, hyoscyamine
auranofin Approved drug Immunopharmacology Ligand 6306 Ridaura®, SK&F-39162, SK-39162
avacincaptad pegol Approved drug 12857 ARC-1905, ARC1905, Izervay®, Zimura
avacopan Approved drug PDB Ligand Immunopharmacology Ligand 9450 CCX-168, CCX168, Tavneos®
avanafil Approved drug PDB Ligand 7448 Spedra®, Stendra®, TA-1790
avapritinib Approved drug Immunopharmacology Ligand 10368 Ayvakit®, Ayvakyt®, BLU-285, BLU285
avatrombopag Approved drug 9953 AKR-501, Doptelet®, E5501, YM477
avelumab Approved drug Immunopharmacology Ligand 8735 Bavencio®, MSB-0010718C, MSB0010718C
avibactam Approved drug PDB Ligand 10761 AVI, NXL 104, NXL-104, NXL104
aviptadil Approved drug 10891 Invicorp® (aviptadil + phentolamine), Vasoactive intestinal octacosapeptide
axitinib Approved drug PDB Ligand 5659 AG 013736, AG-013736, AG013736, Inlyta®
azacitidine Approved drug PDB Ligand Immunopharmacology Ligand 6796 5-AZAC, 5-azacytidine, ladakamycin, Onureg®, Onureg® (CC-486; oral azacitidine), U-18496, Vidaza®
azasetron Approved drug 2285 Y-25130
azatadine Approved drug Immunopharmacology Ligand 7119 Optimine®, SCH-10649
azathioprine Approved drug Immunopharmacology Ligand 7120 Azasan®, BW-57-322, Imuran®, Jayempi®
azelaic acid Approved drug PDB Ligand Immunopharmacology Ligand 7484 Azelex®, Finacea®, ZK-62498
azelastine Approved drug 7121 A-5610, Astelin®, E-0659, Rhinolast®, W-2979M
azidamfenicol Approved drug 12397 azidamphenicol, azidoamfenicol, azidoamphenicol, Thilocof®
azilsartan medoxomil Approved drug 6900 Edarbi®, TAK 491
azithromycin Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6510
azlocillin Approved drug 12260 Azlin®, BAY-E-6905
aztreonam Approved drug 10763 Azactam®, Cayston®, SQ 26776, SQ-26776, SQ26776
B Back to top
bacampicillin Approved drug 12292 Penglobe®, Spectrobid®
bacitracin A Approved drug 12812
baclofen Approved drug 1084 Baclon®, Kemstro®, Lioresal®
baloxavir marboxil Approved drug 11748 S-033188, S033188, Xofluza®
balsalazide Approved drug 11569 Colazal®, Colazide®, Giazo®
bambuterol Approved drug 6601 Bambec®, Oxeol®
baricitinib Approved drug PDB Ligand Immunopharmacology Ligand 7792 INCB-028050, INCB028050, LY-3009104, LY3009104, Olumiant®
basiliximab Approved drug Immunopharmacology Ligand 6879 CHI-621, L04AC02, SDZ-CHI-621, Simulect®
bazedoxifene Approved drug PDB Ligand 7355 Conbriza®, TSE-424, Viviant®, WAY-140424
beclometasone Approved drug PDB Ligand Immunopharmacology Ligand 7059 beclomethasone, SCH-18020W
beclometasone dipropionate Approved drug Immunopharmacology Ligand 5894 beclomethasone dipropionate, Beconase®, Qnasl®, Vancenase®
bedaquiline Approved drug PDB Ligand 11171 BDQ, compound 1a [PMID: 17496888], R-207910, Sirturo®, TMC-207, TMC207
befotertinib Approved drug 12951 compound 4 [WO2019218987A1], D-0316, D0316, Surmana®
beinaglutide Approved drug 12863 Feisumei®
bekanamycin Approved drug PDB Ligand 12182 kanamycin B, nebramycin V
belantamab mafodotin Approved drug Immunopharmacology Ligand 11117 belamaf, belantamab mafodotin-blmf, Blenrep®, GSK-2857916, GSK2857916
belatacept Approved drug Immunopharmacology Ligand 6892 BMS-224818, LEA29Y, Nulojix®
belimumab Approved drug Immunopharmacology Ligand 6887 Benlysta®, hBlySmAb-1.1, LimphoStat-B, lymphostat-B
belinostat Approved drug PDB Ligand 7496 Beleodaq®, PXD-101, PXD101
belumosudil Approved drug PDB Ligand Immunopharmacology Ligand