iloprost [Ligand Id: 1895] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL236025
  • DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
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  • EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
  • EP1 receptor in Mouse [GtoPdb: 340] [UniProtKB: P35375]
  • EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
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  • EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116]
  • EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053]
  • EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
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  • EP3 receptor in Human [GtoPdb: 342] [UniProtKB: P43115]
  • EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
  • EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
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  • EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
  • EP4 receptor in Mouse [GtoPdb: 343] [UniProtKB: P32240]
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  • FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
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  • IP receptor in Human [GtoPdb: 345] [UniProtKB: P43119]
  • IP receptor in Mouse [GtoPdb: 345] [UniProtKB: P43252]
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  • TP receptor in Human [GtoPdb: 346] [UniProtKB: P21731]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
GtoPdb - - 6.6 pKi - - - Br. J. Pharmacol. (1998) 123: 1317-24 [PMID:9579725];
Biochim. Biophys. Acta (2000) 1483: 285-93 [PMID:10634944];
Biochem. Pharmacol. (2012) 84: 68-75 [PMID:22480736]
EP1 receptor in Human [GtoPdb: 340] [UniProtKB: P34995]
GtoPdb - - 8 pKi - - - Biochim. Biophys. Acta (2000) 1483: 285-93 [PMID:10634944];
J. Pharm. Pharmacol. (2002) 54: 539-47 [PMID:11999132]
EP1 receptor in Mouse [GtoPdb: 340] [UniProtKB: P35375]
GtoPdb - - 7.7 pKi - - - Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]
EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
GtoPdb - - 7.9 pKi - - - Eur. J. Pharmacol. (1997) 340: 227-41 [PMID:9537820]
EP2 receptor in Human [GtoPdb: 341] [UniProtKB: P43116]
GtoPdb - - 5.7 pKi - - - Biochim. Biophys. Acta (2000) 1483: 285-93 [PMID:10634944]
EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053]
GtoPdb - - 5.8 pKi - - - Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]
EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
GtoPdb - - 5.9 pKi - - - Eur. J. Pharmacol. (1997) 340: 227-41 [PMID:9537820]
EP3 receptor in Human [GtoPdb: 342] [UniProtKB: P43115]
GtoPdb - - 6.68 pKi 208 nM Ki Biochem. Pharmacol. (2012) 84: 68-75 [PMID:22480736]
GtoPdb - - 7.25 pKi 56 nM Ki Biochim. Biophys. Acta (2000) 1483: 285-93 [PMID:10634944]
EP3 receptor in Mouse [GtoPdb: 342] [UniProtKB: P30557]
GtoPdb - - 7.66 pKi 22 nM Ki Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]
EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980]
GtoPdb - - 7.33 pKi 47 nM Ki Eur. J. Pharmacol. (1997) 340: 227-41 [PMID:9537820]
GtoPdb - - 9.2 pEC50 0.63 nM EC50 Eur. J. Pharmacol. (1997) 340: 227-41 [PMID:9537820]
EP4 receptor in Human [GtoPdb: 343] [UniProtKB: P35408]
GtoPdb - - 6.68 pKi 210 nM Ki Biochim. Biophys. Acta (2000) 1483: 285-93 [PMID:10634944];
Br J Pharmacol (2000) 130: 1919-1926 [PMID:10952683];
Biochem. Pharmacol. (2012) 84: 68-75 [PMID:22480736]
GtoPdb - - 6.4 pEC50 400 nM EC50 Biochem. Pharmacol. (2012) 84: 68-75 [PMID:22480736]
EP4 receptor in Mouse [GtoPdb: 343] [UniProtKB: P32240]
GtoPdb - - 5.6 pKi - - - Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]
FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088]
GtoPdb - - 6.2 pKi - - - Biochim. Biophys. Acta (2000) 1483: 285-93 [PMID:10634944]
IP receptor in Human [GtoPdb: 345] [UniProtKB: P43119]
GtoPdb - - 8 pKi - - - Br. J. Pharmacol. (2006) 148: 326-39 [PMID:16604093];
Biochim. Biophys. Acta (2000) 1483: 285-93 [PMID:10634944]
IP receptor in Mouse [GtoPdb: 345] [UniProtKB: P43252]
GtoPdb - - 8 pKi - - - Br. J. Pharmacol. (1997) 122: 217-24 [PMID:9313928]
TP receptor in Human [GtoPdb: 346] [UniProtKB: P21731]
GtoPdb - - 5.2 pKi - - - Biochim. Biophys. Acta (2000) 1483: 285-93 [PMID:10634944]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]