Hot Topics in Pharmacology

Coronavrius Information

We are currently collating information related to SARS-CoV-2 and COVID-19 at a dedicated coronavirus information page. This contains details of ligands and targets relevant to COVID-19 and links to useful resources and publications.

Recent publications of interest recommended by NC-IUPHAR

2021: Oct | Sep | Aug | Jul | Jun | May | Apr | Mar | Feb | Jan
2020: Dec | Nov

    October 2021


  • The risks of using unapproved gene symbols.
    Braschi B, Seal RL, Tweedie S, Jones TEM, Bruford EA. The risks of using unapproved gene symbols. (2021)  Am J Hum Genet, 108 (10): 1813-1816. [PMID:34626580]

  • Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK.
    Hsu CC, Zhang X, Wang G, Zhang W, Cai Z, Pan BS, Gu H, Xu C, Jin G, Xu X et al.. Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK. (2021)  Mol Cell, 81 (18): 3803-3819.e7. [PMID:34547240]

  • Association of physical activity intensity and bout length with mortality: An observational study of 79,503 UK Biobank participants.
    Millard LAC, Tilling K, Gaunt TR, Carslake D, Lawlor DA. Association of physical activity intensity and bout length with mortality: An observational study of 79,503 UK Biobank participants. (2021)  PLoS Med, 18 (9): e1003757. [PMID:34525088]

  • Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study.
    Hastie KM, Li H, Bedinger D, Schendel SL, Dennison SM, Li K, Rayaprolu V, Yu X, Mann C, Zandonatti M et al.. Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study. (2021)  Science,: eabh2315 [Epub ahead of print]. [PMID:34554826]

  • The G protein database, GproteinDb.
    Pándy-Szekeres G, Esguerra M, Hauser AS, Caroli J, Munk C, Pilger S, Keserű GM, Kooistra AJ, Gloriam DE. The G protein database, GproteinDb. (2021)  Nucleic Acids Res, [Epub ahead of print]. [PMID:34570219]

  • The biological and clinical significance of emerging SARS-CoV-2 variants.
    Tao K, Tzou PL, Nouhin J, Gupta RK, de Oliveira T, Kosakovsky Pond SL, Fera D, Shafer RW. The biological and clinical significance of emerging SARS-CoV-2 variants. (2021)  Nat Rev Genet, [Epub ahead of print]. [PMID:34535792]

  • Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling.
    Hu J, Wang C, Huang X, Yi S, Pan S, Zhang Y, Yuan G, Cao Q, Ye X, Li H. Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling. (2021)  Cell Rep, 36 (12): 109726. [PMID:34551302]

  • Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics.
    Kiss M, Mbasu R, Nicolaï J, Barnouin K, Kotian A, Mooij MG, Kist N, Wijnen RMH, Ungell AL, Cutler P et al.. Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics. (2021)  Drug Metab Dispos, [Epub ahead of print]. [PMID:34548392]

  • Reading ADP-ribosylation signaling using chemical biology and interaction proteomics.
    Kliza KW, Liu Q, Roosenboom LWM, Jansen PWTC, Filippov DV, Vermeulen M. Reading ADP-ribosylation signaling using chemical biology and interaction proteomics. (2021)  Mol Cell, [Epub ahead of print]. [PMID:34551281]

  • Structural basis of gating modulation of Kv4 channel complexes.
    Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O. Structural basis of gating modulation of Kv4 channel complexes. (2021)  Nature, [Epub ahead of print]. [PMID:34552243]

  • The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.
    Lawrence JM, Meyerowitz-Katz G, Heathers JAJ, Brown NJL, Sheldrick KA. The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable. (2021)  Nat Med, [Epub ahead of print]. [PMID:34552263]

  • September 2021


  • Insights into the expanding phenotypic spectrum of inherited disorders of biogenic amines.
    Kuseyri Hübschmann O, Horvath G, Cortès-Saladelafont E, Yıldız Y, Mastrangelo M, Pons R, Friedman J, Mercimek-Andrews S, Wong SN, Pearson TS et al.. Insights into the expanding phenotypic spectrum of inherited disorders of biogenic amines. (2021)  Nat Commun, 12 (1): 5529. [PMID:34545092]

  • Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers.
    Begley CG, Ashton M, Baell J, Bettess M, Brown MP, Carter B, Charman WN, Davis C, Fisher S, Frazer I et al.. Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers. (2021)  Sci Transl Med, 13 (612): eabd5524. [PMID:34550729]

  • Structures of the human cholecystokinin receptors bound to agonists and antagonists.
    Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X et al.. Structures of the human cholecystokinin receptors bound to agonists and antagonists. (2021)  Nat Chem Biol, [Epub ahead of print]. [PMID:34556863]

  • Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor.
    Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C et al.. Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor. (2021)  Nat Chem Biol, [Epub ahead of print]. [PMID:34556862]

  • Clinical Lipidomics: Realizing the potential of lipid profiling.
    Meikle TG, Huynh K, Giles C, Meikle PJ. Clinical Lipidomics: Realizing the potential of lipid profiling. (2021)  J Lipid Res,: 100127 [Epub ahead of print]. [PMID:34582882]

  • Examining Gender Imbalance in Chemistry Authorship.
    Cotton AD, Seiple IB. Examining Gender Imbalance in Chemistry Authorship. (2021)  ACS Chem Biol, [Epub ahead of print]. [PMID:34523912]

  • Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC).
    Madjroh N, Mellou E, Æbelø L, Davies PA, Söderhielm PC, Jensen AA. Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC). (2021)  Biochem Pharmacol,: 114781 [Epub ahead of print]. [PMID:34560053]

  • Ligandability of E3 Ligases for Targeted Protein Degradation Applications.
    Belcher BP, Ward CC, Nomura DK. Ligandability of E3 Ligases for Targeted Protein Degradation Applications. (2021)  Biochemistry, [Epub ahead of print]. DOI: 10.1021/acs.biochem.1c00464 [PMID:34473924]

  • Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome.
    Zhang K, Zheludev IN, Hagey RJ, Haslecker R, Hou YJ, Kretsch R, Pintilie GD, Rangan R, Kladwang W, Li S et al.. Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome. (2021)  Nat Struct Mol Biol, [Epub ahead of print]. DOI: 10.1038/s41594-021-00653-y [PMID:34426697]

  • SLC-30A9 is required for Zn2+ homeostasis, Zn2+ mobilization, and mitochondrial health.
    Deng H, Qiao X, Xie T, Fu W, Li H, Zhao Y, Guo M, Feng Y, Chen L, Zhao Y et al.. SLC-30A9 is required for Zn2+ homeostasis, Zn2+ mobilization, and mitochondrial health. (2021)  Proc Natl Acad Sci U S A, 118 (35). DOI: 10.1073/pnas.2023909118 [PMID:34433664]

  • Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity.
    Liu C, Jursa T, Aschner M, Smith DR, Mukhopadhyay S. Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity. (2021)  Proc Natl Acad Sci U S A, 118 (35). DOI: 10.1073/pnas.2107673118 [PMID:34446561]

  • Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis.
    Tapmeier TT, Rahmioglu N, Lin J, De Leo B, Obendorf M, Raveendran M, Fischer OM, Bafligil C, Guo M, Harris RA et al.. Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis. (2021)  Sci Transl Med, 13 (608). DOI: 10.1126/scitranslmed.abd6469 [PMID:34433639]

  • Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A3 Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary.
    Lee Y, Hou X, Lee JH, Nayak A, Alexander V, Sharma PK, Chang H, Phan K, Gao ZG, Jacobson KA et al.. Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A3 Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. (2021)  J Med Chem, [Epub ahead of print]. DOI: 10.1021/acs.jmedchem.1c00239 [PMID:34435786]

  • Will the chemical probes please stand up?.
    Škuta C, Southan C, Bartůněk P. Will the chemical probes please stand up?. (2021)  RSC Med Chem, 12 (8): 1428-1441. [PMID:34447939]

  • August 2021


  • Rare variant contribution to human disease in 281,104 UK Biobank exomes.
    Wang Q, Dhindsa RS, Carss K, Harper AR, Nag A, Tachmazidou I, Vitsios D, Deevi SVV, Mackay A, Muthas D et al.. Rare variant contribution to human disease in 281,104 UK Biobank exomes. (2021)  Nature, [Epub ahead of print]. [PMID:34375979]

  • Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis.
    Pavord S, Scully M, Hunt BJ, Lester W, Bagot C, Craven B, Rampotas A, Ambler G, Makris M. Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis. (2021)  N Engl J Med, [Epub ahead of print]. [PMID:34379914]

  • Leslie Iversen, a friend of friends and an inspiring light in neuropharmacology.
    Cuello AC. Leslie Iversen, a friend of friends and an inspiring light in neuropharmacology. (2021)  Proc Natl Acad Sci U S A, 118 (32). [PMID:34353919]

  • Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas.
    Matta JA, Gu S, Davini WB, Bredt DS. Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas. (2021)  Science, 373 (6556). [PMID:34385370]

  • Anti-Platelet Drugs Block Platelet Activation by Vaccine-Induced Immune Thrombocytopenia and Thrombosis Patient Serum.
    Smith CW, Montague SJ, Kardeby C, DI Y, Lowe GC, Lester WA, Watson SP, Nicolson PLR. Anti-Platelet Drugs Block Platelet Activation by Vaccine-Induced Immune Thrombocytopenia and Thrombosis Patient Serum. (2021)  Blood, [Epub ahead of print]. DOI: 10.1182/blood.2021012277 [PMID:34375398]

  • Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics.
    Kanai Y. Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics. (2021)  Pharmacol Ther,: 107964 [Epub ahead of print]. [PMID:34390745]

  • Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor.
    Burger WAC, Gentry PR, Berizzi AE, Vuckovic Z, van der Westhuizen ET, Thompson G, Yeasmin M, Lindsley CW, Sexton PM, Langmead CJ et al.. Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor. (2021)  ACS Chem Neurosci, [Epub ahead of print]. [PMID:34351123]

  • Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy.
    Moehle MS, Bender AM, Dickerson JW, Foster DJ, Qi A, Cho HP, Donsante Y, Peng W, Bryant Z, Stillwell KJ et al.. Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy. (2021)  ACS Pharmacol. Transl. Sci., [Epub ahead of print]. DOI: 10.1021/acsptsci.0c00162

  • The residence of synaptically released dopamine on D2 autoreceptors.
    Condon AF, Robinson BG, Asad N, Dore TM, Tian L, Williams JT. The residence of synaptically released dopamine on D2 autoreceptors. (2021)  Cell Rep, 36 (5): 109465. [PMID:34348146]

  • Antisense oligonucleotide-mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice.
    Bell 3rd TA, Liu M, Donner AJ, Lee RG, Mullick AE, Crooke RM. Antisense oligonucleotide-mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice. (2021)  J Lipid Res,: 100101 [Epub ahead of print]. [PMID:34371033]

  • The structural basis of odorant recognition in insect olfactory receptors.
    Del Mármol J, Yedlin MA, Ruta V. The structural basis of odorant recognition in insect olfactory receptors. (2021)  Nature, [Epub ahead of print]. [PMID:34349260]

  • Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors.
    Donthamsetti P, Winter N, Hoagland A, Stanley C, Visel M, Lammel S, Trauner D, Isacoff E. Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors. (2021)  Nat Commun, 12 (1): 4775. [PMID:34362914]

  • Cryo-EM structure of the human MT1-Gi signaling complex.
    Okamoto HH, Miyauchi H, Inoue A, Raimondi F, Tsujimoto H, Kusakizako T, Shihoya W, Yamashita K, Suno R, Nomura N et al.. Cryo-EM structure of the human MT1-Gi signaling complex. (2021)  Nat Struct Mol Biol, [Epub ahead of print]. [PMID:34354246]

  • Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants.
    Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, Zhu H, Anand K, Tong P, Gautam A et al.. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. (2021)  Science, 373 (6555): 642-648. [PMID:34168070]

  • Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
    Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K et al.. Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. (2021)  Science, 373 (6555). [PMID:34168071]

  • A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma.
    Fenwick C, Turelli P, Pellaton C, Farina A, Campos J, Raclot C, Pojer F, Cagno V, Nusslé SG, D'Acremont V et al.. A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma. (2021)  Sci Transl Med, 13 (605). [PMID:34257144]

  • An Oral SARS-CoV-2 Mpro Inhibitor Clinical Candidate for the Treatment of COVID-19.
    Owen DR, Allerton CMN, Anderson AS, Aschenbrenner L, Avery M, Berritt S, Boras B, Cardin RD, Carlo A, Karen Coffman et al.. An Oral SARS-CoV-2 Mpro Inhibitor Clinical Candidate for the Treatment of COVID-19. (2021)  medRxiv, [Preprint]. DOI: 10.1101/2021.07.28.21261232

  • Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection.
    Williams TL, Colzani MT, Macrae RGC, Robinson EL, Bloor S, Greenwood EJD, Zhan JR, Strachan G, Kuc RE, Nyimanu D et al.. Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection. (2021)  Commun Biol, 4 (1): 926. [PMID:34326460]

  • Discovering and Summarizing Relationships Between Chemicals, Genes, Proteins, and Diseases in PubChem.
    Zaslavsky L, Cheng T, Gindulyte A, He S, Kim S, Li Q, Thiessen P, Yu B, Bolton EE. Discovering and Summarizing Relationships Between Chemicals, Genes, Proteins, and Diseases in PubChem. (2021)  Front Res Metr Anal, 6: 689059. [PMID:34322655]

  • Hot Topics: Trends in kinase drug discovery: twenty years of successfully targeting the kinome

    Comments by Misty Attwood and Helgi Schiöth, University of Uppsala, Uppsala, Sweden.

    The FDA approval of imatinib in 2001 was a breakthrough in molecularly targeted cancer therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology area and beyond.. Read the full article on our blog

  • Sphingomyelin synthase related protein is a mammalian phosphatidylethanolamine phospholipase C.
    Chiang YP, Li Z, Chen Y, Cao Y, Jiang XC. Sphingomyelin synthase related protein is a mammalian phosphatidylethanolamine phospholipase C. (2021)  Biochim Biophys Acta Mol Cell Biol Lipids, 1866 (11): 159017 [Epub ahead of print]. [PMID:34332077]

  • Gene name errors: Lessons not learned
    Abeysooriya M, Soria M, Kasu MS, Ziemann M. Gene name errors: Lessons not learned. (2021)  PLoS Comput Biol, 17 (7): e1008984 [Epub ahead of print]. [PMID:34329294]
    Lewis D. Autocorrect errors in Excel still creating genomics headache. (2021)  Nature, [Epub ahead of print]. [PMID:34389840]

  • GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain.
    Leurs U, Klein AB, McSpadden ED, Griem-Krey N, Solbak SMØ, Houlton J, Villumsen IS, Vogensen SB, Hamborg L, Gauger SJ et al.. GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain. (2021)  Proc Natl Acad Sci U S A, 118 (31). [PMID:34330837]

  • Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span.
    Grunewald M, Kumar S, Sharife H, Volinsky E, Gileles-Hillel A, Licht T, Permyakova A, Hinden L, Azar S, Friedmann Y et al.. Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span. (2021)  Science, 373 (6554). [PMID:34326210]

  • Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS.
    Coyne AN, Baskerville V, Zaepfel BL, Dickson DW, Rigo F, Bennett F, Lusk CP, Rothstein JD. Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS. (2021)  Sci Transl Med, 13 (604). [PMID:34321318]

  • July 2021


  • The PROTACtable genome.
    Schneider M, Radoux CJ, Hercules A, Ochoa D, Dunham I, Zalmas LP, Hessler G, Ruf S, Shanmugasundaram V, Hann MM et al.. The PROTACtable genome. (2021)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:34285415]

  • Identifying the core concepts of pharmacology education.
    White PJ, Davis EA, Santiago M, Angelo T, Shield A, Babey AM, Kemp-Harper B, Maynard G, Al-Sallami HS, Musgrave IF et al.. Identifying the core concepts of pharmacology education. (2021)  Pharmacol Res Perspect, 9 (4): e00836. [PMID:34288559]

  • Sulfatides are endogenous ligands for the TLR4-MD-2 complex.
    Su L, Athamna M, Wang Y, Wang J, Freudenberg M, Yue T, Wang J, Moresco EMY, He H, Zor T et al.. Sulfatides are endogenous ligands for the TLR4-MD-2 complex. (2021)  Proc Natl Acad Sci U S A, 118 (30). [PMID:34290146]

  • Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
    Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S et al.. Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. (2021)  Science, [Epub ahead of print]. [PMID:34285133]

  • Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data.
    van der Lee M, Allard WG, Vossen RHAM, Baak-Pablo RF, Menafra R, Deiman BALM, Deenen MJ, Neven P, Johansson I, Gastaldello S et al.. Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data. (2021)  Sci Transl Med, 13 (603). [PMID:34290055]

  • The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
    Murithi JM, Pascal C, Bath J, Boulenc X, Gnädig NF, Pasaje CFA, Rubiano K, Yeo T, Mok S, Klieber S et al.. The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance. (2021)  Sci Transl Med, 13 (603). [PMID:34290058]

  • Molecular topography of an entire nervous system.
    Taylor SR, Santpere G, Weinreb A, Barrett A, Reilly MB, Xu C, Varol E, Oikonomou P, Glenwinkel L, McWhirter R et al.. Molecular topography of an entire nervous system. (2021)  Cell, [Epub ahead of print]. [PMID:34237253]

  • Structure of human Cav2.2 channel blocked by the painkiller ziconotide.
    Gao S, Yao X, Yan N. Structure of human Cav2.2 channel blocked by the painkiller ziconotide. (2021)  Nature, [Epub ahead of print]. [PMID:34234349]

  • Mapping the human genetic architecture of COVID-19.
    COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. (2021)  Nature, [Epub ahead of print]. [PMID:34237774]

  • Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
    Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI. Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. (2021)  Nat Struct Mol Biol, 28 (7): 564-572. [PMID:34239124]

  • Heat-dependent opening of TRPV1 in the presence of capsaicin.
    Kwon DH, Zhang F, Suo Y, Bouvette J, Borgnia MJ, Lee SY. Heat-dependent opening of TRPV1 in the presence of capsaicin. (2021)  Nat Struct Mol Biol, 28 (7): 554-563. [PMID:34239123]

  • 2020 in review: FDA approvals of new medicines.
    Kinch MS, Kraft Z, Schwartz T. 2020 in review: FDA approvals of new medicines. (2021)  Drug Discov Today, [Epub ahead of print]. [PMID:34252611]

  • Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank.
    Szustakowski JD, Balasubramanian S, Kvikstad E, Khalid S, Bronson PG, Sasson A, Wong E, Liu D, Wade Davis J, Haefliger C et al.. Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank. (2021)  Nat Genet, 53 (7): 942-948. [PMID:34183854]

  • Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems.
    Schmidl S, Ursu O, Iancu CV, Oreb M, Oprea TI, Choe JY. Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems. (2021)  Sci Rep, 11 (1): 13751. [PMID:34215797]

  • Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
    Lowe D. Drug Repurposing for Coronaviruses: Be Careful.  In the Pipeline, https://blogs.sciencemag.org/pipeline/archives/2021/06/25/drug-repurposing-for-coronaviruses-be-careful
    Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, White KM, Zhang Z, Alon A et al.. Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. (2021)  Science, 373 (6554): 541-547. [PMID:34326236]

  • The language of race, ethnicity, and ancestry in human genetic research.
    Birney E, Inouye M, Raff J, Rutherford A, Scally A. The language of race, ethnicity, and ancestry in human genetic research. (2021)  arXiv, Preprint.

  • June 2021


  • Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4.
    Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X et al.. Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4. (2021)  Nature, [Epub ahead of print]. [PMID:34135510]

  • Structures of human mGlu2 and mGlu7 homo- and heterodimers.
    Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T et al.. Structures of human mGlu2 and mGlu7 homo- and heterodimers. (2021)  Nature, [Epub ahead of print]. [PMID:34135509]

  • SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation.
    Sanders DW, Jumper CC, Ackerman PJ, Bracha D, Donlic A, Kim H, Kenney D, Castello-Serrano I, Suzuki S, Tamura T et al.. SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. (2021)  Elife, 10. [PMID:33890572]

  • Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
    Cater RJ, Chua GL, Erramilli SK, Keener JE, Choy BC, Tokarz P, Chin CF, Quek DQY, Kloss B, Pepe JG et al.. Structural basis of omega-3 fatty acid transport across the blood-brain barrier. (2021)  Nature, [Epub ahead of print]. [PMID:34135507]

  • A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects.
    Pryce KD, Kang HJ, Sakloth F, Liu Y, Khan S, Toth K, Kapoor A, Nicolais A, Che T, Qin L et al.. A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects. (2021)  Neuropharmacology, In Press. DOI: 10.1016/j.neuropharm.2021.108673

  • The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration.
    Hoare SRJ. The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration. (2021)  SLAS Discov,: 24725552211019653 [Epub ahead of print]. [PMID:34112012]

  • Landmark Alzheimer's drug approval confounds research community.
    Mullard A. Landmark Alzheimer's drug approval confounds research community. (2021)  Nature, [Epub ahead of print]. [PMID:34103732]

  • Rationality over fashion and hype in drug design.
    Medina-Franco JL, Martinez-Mayorga K, Fernández-de Gortari E, Kirchmair J, Bajorath J. Rationality over fashion and hype in drug design. (2021)  F1000Res, Preprint. DOI: 10.12688/f1000research.52676.1

  • Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.
    Hodcroft EB, Zuber M, Nadeau S, Vaughan TG, Crawford KHD, Althaus CL, Reichmuth ML, Bowen JE, Walls AC, Corti D et al.. Spread of a SARS-CoV-2 variant through Europe in the summer of 2020. (2021)  Nature, [Epub ahead of print]. [PMID:34098568]

  • Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease.
    Horowitz JE, Kosmicki JA, Damask A, Sharma D, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Yadav A, Leader JB et al.. Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease. (2021)  medrxiv, Preprint. DOI: 10.1101/2020.12.14.20248176

  • May 2021


  • Pharmacogenetics at Scale: An Analysis of the UK Biobank.
    McInnes G, Lavertu A, Sangkuhl K, Klein TE, Whirl-Carrillo M, Altman RB. Pharmacogenetics at Scale: An Analysis of the UK Biobank. (2021)  Clin Pharmacol Ther, 109 (6): 1528-1537. [PMID:33237584]

  • Assessing the functional relevance of splice isoforms.
    Pozo F, Martinez-Gomez L, Walsh TA, Rodriguez JM, Di Domenico T, Abascal F, Vazquez J, Tress ML. Assessing the functional relevance of splice isoforms. (2021)  NAR Genom Bioinform, 3 (2): lqab044. [PMID:34046593]

  • Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.
    Levey DF, Stein MB, Wendt FR, Pathak GA, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C et al.. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions. (2021)  Nat Neurosci, [Epub ahead of print]. [PMID:34045744]

  • Next generation plasma proteome profiling to monitor health and disease.
    Zhong W, Edfors F, Gummesson A, Bergström G, Fagerberg L, Uhlén M. Next generation plasma proteome profiling to monitor health and disease. (2021)  Nat Commun, 12 (1): 2493. [PMID:33941778]

  • The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin.
    Peacock TP, Sheppard CM, Brown JC, Goonawardane N, Zhou J, Whiteley M, PHE Virology Consortium, de Silva TI, Barclay WS. The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin.   bioRxiv, Preprint. DOI: 10.1101/2021.05.28.446163

  • The complete sequence of a human genome.
    Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze AV, Mikheenko A, Vollger MR, Altemose N, Uralsky L, Gershman A et al.. The complete sequence of a human genome. (2021)  bioRxiv, Preprint. DOI: 10.1101/2021.05.26.445798

  • Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries.
    Islam N, Shkolnikov VM, Acosta RJ, Klimkin I, Kawachi I, Irizarry RA, Alicandro G, Khunti K, Yates T, Jdanov DA et al.. Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries. (2021)  BMJ, 373: n1137. [PMID:34011491]

  • April 2021


  • RECOVERY 1 year on: a rare success in the COVID-19 clinical trial landscape.
    Mullard A. RECOVERY 1 year on: a rare success in the COVID-19 clinical trial landscape. (2021)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:33864035]

  • Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
    Gaziano L, Giambartolomei C, Pereira AC, Gaulton A, Posner DC, Swanson SA, Ho YL, Iyengar SK, Kosik NM, Vujkovic M et al.. Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19. (2021)  Nat Med, 27 (4): 668-676. [PMID:33837377]

  • The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice.
    Dekeryte R, Franklin Z, Hull C, Croce L, Kamli-Salino S, Helk O, Hoffmann PA, Yang Z, Riedel G, Delibegovic M et al.. The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice. (2021)  Biochim Biophys Acta Mol Basis Dis, 1867 (7): 166149 [Epub ahead of print]. [PMID:33892080]

  • Novel drug targets in 2020.
    Avram S, Halip L, Curpan R, Oprea TI. Novel drug targets in 2020. (2021)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:33824485]

  • The Promise and Peril of Chemical Probe Negative Controls.
    Lee J, Schapira M. The Promise and Peril of Chemical Probe Negative Controls. (2021)  ACS Chem Biol, [Epub ahead of print]. [PMID:33745272]

  • Road to effective data curation for translational research.
    Gu W, Hasan S, Rocca-Serra P, Satagopam VP. Road to effective data curation for translational research. (2021)  Drug Discov Today, 26 (3): 626-630. [PMID:33338655]

  • The evolving role of preprints in the dissemination of COVID-19 research and their impact on the science communication landscape.
    Fraser N, Brierley L, Dey G, Polka JK, Pálfy M, Nanni F, Coates JA. The evolving role of preprints in the dissemination of COVID-19 research and their impact on the science communication landscape. (2021)  PLoS Biol, 19 (4): e3000959 [Epub ahead of print]. [PMID:33798194]

  • A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.
    Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI et al.. A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells. (2021)  ACS Chem Biol, 16 (4): 642-650. [PMID:33787221]

  • COVID vaccines and blood clots: five key questions
    Ledford H. COVID vaccines and blood clots: five key questions. (2021)  Nature, 592 (7855): 495-496. [PMID:33864049]
    Ledford H. How could a COVID vaccine cause blood clots? Scientists race to investigate. (2021)  Nature, 592 (7854): 334-335. [PMID:33846607]

  • Biden pursues giant boost for science spending.
    Tollefson J, Maxmen A, Remmel A, Subbaraman N, Witze A. Biden pursues giant boost for science spending. (2021)  Nature, 592 (7855): 498-499. [PMID:33846608]

  • Structural insights into the lipid and ligand regulation of serotonin receptors.
    Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV et al.. Structural insights into the lipid and ligand regulation of serotonin receptors. (2021)  Nature, [Epub ahead of print]. [PMID:33762731]

  • March 2021


  • The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans.
    Smith BAH, Bertozzi CR. The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans. (2021)  Nat Rev Drug Discov, 20 (3): 217-243. [PMID:33462432]

  • Signals of hope: gauging the impact of a rapid national vaccination campaign.
    Shilo S, Rossman H, Segal E. Signals of hope: gauging the impact of a rapid national vaccination campaign. (2021)  Nat Rev Immunol, [Epub ahead of print]. [PMID:33712744]

  • AI and Drug Discovery: Attacking the Right Problems
    Bender A, Cortes-Ciriano I. Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 2: a discussion of chemical and biological data. (2021)  Drug Discov Today, [Epub ahead of print]. [PMID:33508423]
    Bender A, Cortés-Ciriano I. Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 1: Ways to make an impact, and why we are not there yet. (2021)  Drug Discov Today, 26 (2): 511-524. [PMID:33346134]
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  • Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
    Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP et al.. Structural insights into the human D1 and D2 dopamine receptor signaling complexes. (2021)  Cell, 184 (4): 931-942.e18. [PMID:33571431]

  • Trends in COVID-19 therapeutic clinical trials.
    Bugin K, Woodcock J. Trends in COVID-19 therapeutic clinical trials. (2021)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:33633370]

  • Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.
    Yeung ML, Teng JLL, Jia L, Zhang C, Huang C, Cai JP, Zhou R, Chan KH, Zhao H, Zhu Let al.. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. (2021)  Cell, Preprint. DOI: 10.1016/j.cell.2021.02.053

  • February 2021


  • Constitutive G protein coupling profiles of understudied orphan GPCRs.
    Lu S, Jang W, Inoue A, Lambert NA. Constitutive G protein coupling profiles of understudied orphan GPCRs. (2021)  PLoS One, 16 (4): e0247743. [PMID:33886554]

  • Structure and inhibition mechanism of the human citrate transporter NaCT.
    Sauer DB, Song J, Wang B, Hilton JK, Karpowich NK, Mindell JA, Rice WJ, Wang DN. Structure and inhibition mechanism of the human citrate transporter NaCT. (2021)  Nature, [Epub ahead of print]. [PMID:33597751]

  • Structures of the human dopamine D3 receptor-Gi complexes.
    Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y et al.. Structures of the human dopamine D3 receptor-Gi complexes. (2021)  Mol Cell, [Epub ahead of print]. [PMID:33548201]

  • Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
    Dorjsuren D, Eastman RT, Wicht KJ, Jansen D, Talley DC, Sigmon BA, Zakharov AV, Roncal N, Girvin AT, Antonova-Koch Y et al.. Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites. (2021)  Sci Rep, 11 (1): 2121. [PMID:33483532]

  • Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.
    Tree JA, Turnbull JE, Buttigieg KR, Elmore MJ, Coombes N, Hogwood J, Mycroft-West CJ, Lima MA, Skidmore MA, Karlsson R et al.. Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. (2021)  Br J Pharmacol, 178 (3): 626-635. [PMID:33125711]

  • Identification of the Core Chemical Structure in SureChEMBL Patents.
    Falaguera MJ, Mestres J. Identification of the Core Chemical Structure in SureChEMBL Patents. (2021)  J Chem Inf Model, 61 (5): 2241-2247. [PMID:33929850]

  • SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor.
    Zahradník J, Marciano S, Shemesh M, Zoler E, Chiaravalli J, Meyer B, Rudich Y, Dym O, Elad N, Schreiber G. SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor. (2021)  bioRxiv, Preprint. DOI: 10.1101/2021.01.06.425392

  • January 2021


  • CoV3D: a database of high resolution coronavirus protein structures.
    Gowthaman R, Guest JD, Yin R, Adolf-Bryfogle J, Schief WR, Pierce BG. CoV3D: a database of high resolution coronavirus protein structures. (2021)  Nucleic Acids Res, 49 (D1): D282-D287. [PMID:32890396]

  • Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies.
    Greaney AJ, Loes AN, Crawford KHD, Starr TN, Malone KD, Chu HY, Bloom JD. Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies. (2021)  Cell Host Microbe, 29 (3): 463-476.e6. [PMID:33592168]

  • The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres.
    Stephenson E, Reynolds G, Botting RA, Calero-Nieto FJ, Morgan M, Tuong ZK, Bach K, Sungnak W, Worlock KB, Yoshida M et al.. The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres. (2021)  MedRxiv, Preprint. DOI: 10.1101/2021.01.13.21249725

  • The role of orphan receptor GPR139 in neuropsychiatric behavior.
    Dao M, Stoveken HM, Cao Y, Martemyanov KA. The role of orphan receptor GPR139 in neuropsychiatric behavior. (2021)  Neuropsychopharmacology, [Epub ahead of print]. [PMID:33479510]

  • Hot Topics: Gene Symbol usage and the need to do better

    Comments by Chris Southan, Fellow of the University of Edinburgh, Owner of TW2Informatics, Chair of NC-IUPHAR Subcommitees for Proteases and Drug Targets and Chemistry (DRUTACS).

    The GtoPdb team need no convincing about the importance of ameliorating equivocality in gene and gene product names, both as they are used (often incorrectly) in the pharmacology and drug discovery literature. Crucially, this also applies to their inclusion in curated database records such as GtoPdb.. Read the full article on our blog

  • Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases.
    Tabassum R, Ripatti S. Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases. (2021)  Cell Mol Life Sci, [Epub ahead of print]. [PMID:33449144]

  • The influence of evolutionary history on human health and disease.
    Benton ML, Abraham A, LaBella AL, Abbot P, Rokas A, Capra JA. The influence of evolutionary history on human health and disease. (2021)  Nat Rev Genet, [Epub ahead of print]. [PMID:33408383]

  • Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK.
    du Plessis L, McCrone JT, Zarebski AE, Hill V, Ruis C, Gutierrez B, Raghwani J, Ashworth J, Colquhoun R, Connor TR et al.. Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK. (2021)  Science, 371 (6530): 708-712. [PMID:33419936]

  • Evolution of the endothelin pathway drove neural crest cell diversification.
    Square TA, Jandzik D, Massey JL, Romášek M, Stein HP, Hansen AW, Purkayastha A, Cattell MV, Medeiros DM. Evolution of the endothelin pathway drove neural crest cell diversification. (2020)  Nature, 585 (7826): 563-568. [PMID:32939088]

  • December 2020


  • Genetic mechanisms of critical illness in COVID-19.
    Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD et al.. Genetic mechanisms of critical illness in COVID-19. (2021)  Nature, 591 (7848): 92-98. [PMID:33307546]

  • KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies.
    Ávalos Prado P, Häfner S, Comoglio Y, Wdziekonski B, Duranton C, Attali B, Barhanin J, Sandoz G. KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies. (2021)  Cell, 184 (2): 534-544.e11. [PMID:33373586]

  • 'It will change everything': DeepMind's AI makes gigantic leap in solving protein structures
    Callaway E. 'It will change everything': DeepMind's AI makes gigantic leap in solving protein structures. (2020)  Nature, 588 (7837): 203-204. [PMID:33257889]
    Outeiral C. CASP14: what Google DeepMind’s AlphaFold 2 really achieved, and what it means for protein folding, biology and bioinformatics.  Oxford Protein Informatics Group, https://www.blopig.com/blog/2020/12/casp14-what-google-deepminds-alphafold-2-really-achieved-and-what-it-means-for-protein-folding-biology-and-bioinformatics/

  • Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics.
    Walsh MA, Grimes JM, Stuart DI. Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics. (2021)  Biochem Biophys Res Commun, 538: 40-46. [PMID:33248689]

  • November 2020


  • Pathway information extracted from 25 years of pathway figures.
    Hanspers K, Riutta A, Summer-Kutmon M, Pico AR. Pathway information extracted from 25 years of pathway figures. (2020)  Genome Biol, 21 (1): 273. [PMID:33168034]

  • Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data.
    Hu J, Li C, Wang S, Li T, Zhang H. Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data. (2020)  medRxiv, Preprint. DOI: 10.1101/2020.11.05.20226761

  • Combinatorial expression of GPCR isoforms affects signalling and drug responses.
    Marti-Solano M, Crilly SE, Malinverni D, Munk C, Harris M, Pearce A, Quon T, Mackenzie AE, Wang X, Peng J et al.. Combinatorial expression of GPCR isoforms affects signalling and drug responses. (2020)  Nature, 587 (7835): 650-656. [PMID:33149304]

  • Biogen’s Alzheimer’s drug candidate takes a beating from FDA advisers.
    Servick K. Biogen’s Alzheimer’s drug candidate takes a beating from FDA advisers. 
    Accessed on 11/11/2020. Modified on 11/11/2020. https://www.sciencemag.org/news/2020/11/biogen-s-alzheimer-s-drug-candidate-takes-beating-fda-advisers

  • Interferon deficiency can lead to severe COVID
    Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V et al.. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. (2020)  Science, 370 (6515). [PMID:32972996]
    Meffre E, Iwasaki A. Interferon deficiency can lead to severe COVID. (2020)  Nature, 587 (7834): 374-376. [PMID:33139913]
    Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C et al.. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. (2020)  Science, 370 (6515). [PMID:32972995]

  • A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research
    Zahoránszky-Kőhalmi G, Siramshetty VB, Kumar P, Gurumurthy M, Grillo B, Mathew B, Metaxatos D, Backus M, Mierzwa T, Simon R et al.. A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research. (2020)  bioRxiv, Preprint. [PMID:33173863]
    National Center for Advancing Translational Sciences (NCATS). Neo4COVID-19.  https://neo4covid19.ncats.io

  • COVID Moonshot: Open Science Discovery of SARS-CoV-2 Main Protease Inhibitors by Combining Crowdsourcing, High-Throughput Experiments, Computational Simulations, and Machine Learning.
    The COVID Moonshot Consortium. COVID Moonshot: Open Science Discovery of SARS-CoV-2 Main Protease Inhibitors by Combining Crowdsourcing, High-Throughput Experiments, Computational Simulations, and Machine Learning. (2020)  bioRxiv, Preprint. DOI: 10.1101/2020.10.29.339317

  • The ‘very, very bad look’ of remdesivir, the first FDA-approved COVID-19 drug.
    Cohen J, Kupferschmidt K. The ‘very, very bad look’ of remdesivir, the first FDA-approved COVID-19 drug. 
    Accessed on 02/11/2020. Modified on 02/11/2020. https://www.sciencemag.org/news/2020/10/very-very-bad-look-remdesivir-first-fda-approved-covid-19-drug

  • COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms.
    Ostaszewski M, Niarakis A, Mazein A, Kuperstein I, Phair R, Orta-Resendiz A, Singh V, Aghamir SS, Acencio ML, Glaab E et al.. COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms. (2020)  bioRxiv, Preprint. DOI: 10.1101/2020.10.26.356014