Hot Topics in Pharmacology

Coronavrius Information

We are currently collating information related to SARS-CoV-2 and COVID-19 at a dedicated coronavirus information page. This contains details of ligands and targets relevant to COVID-19 and links to useful resources and publications.

Recent publications of interest recommended by NC-IUPHAR

2022: Oct | Sep | Aug | Jul | Jun | May | Apr | Mar | Feb | Jan
2021: Dec

    October 2022


  • Genenames.org: the HGNC resources in 2023.
    Seal RL, Braschi B, Gray K, Jones TEM, Tweedie S, Haim-Vilmovsky L, Bruford EA. Genenames.org: the HGNC resources in 2023. (2022)  Nucleic Acids Res, [Epub ahead of print]. [PMID:36243972]

  • Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID.
    Kwak C, Park C, Ko M, Im CY, Moon H, Park YH, Kim SY, Lee S, Kang MG, Kwon HJ et al.. Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID. (2022)  Cell Chem Biol, [Epub ahead of print]. [PMID:36272407]

  • September 2022


  • Visualizing classification of drugs used in psychotic disorders: A 'subway map' representing mechanisms, established classes and informal categories.
    Zhou C, Nutt DJ, Davies SJ. Visualizing classification of drugs used in psychotic disorders: A 'subway map' representing mechanisms, established classes and informal categories. (2022)  J Psychopharmacol,: 2698811221115758 [Epub ahead of print]. [PMID:36045588]

  • August 2022


  • Environmental pharmacology-Dosing the environment: IUPHAR review 36.
    Connolly CN, Alexander SPH, Davies JA, Spedding M. Environmental pharmacology-Dosing the environment: IUPHAR review 36. (2022)  Br J Pharmacol, [Epub ahead of print]. [PMID:35975296]

  • Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review.
    Wainwright CL, Teixeira MM, Adelson DL, Buenz EJ, David B, Glaser KB, Harata-Lee Y, Howes MR, Izzo AA, Maffia P et al.. Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review. (2022)  Pharmacol Res, 177: 106076. [PMID:35074524]

  • The past, present, and future of antibiotics.
    Cook MA, Wright GD. The past, present, and future of antibiotics. (2022)  Sci Transl Med, 14 (657): eabo7793. [PMID:35947678]

  • Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
    Wyant GA, Yu W, Doulamis IP, Nomoto RS, Saeed MY, Duignan T, McCully JD, Kaelin Jr WG. Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists. (2022)  Science, 377 (6606): 621-629. [PMID:35926043]

  • Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias.
    Schihada H, Klompstra TM, Humphrys LJ, Cervenka I, Dadvar S, Kolb P, Ruas JL, Schulte G. Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias. (2022)  J Biol Chem,: 102328 [Epub ahead of print]. [PMID:35933013]

  • Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase.
    Swale C, Bellini V, Bowler MW, Flore N, Brenier-Pinchart MP, Cannella D, Belmudes L, Mas C, Couté Y, Laurent F et al.. Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase. (2022)  Sci Transl Med, 14 (656): eabn3231. [PMID:35921477]

  • July 2022


  • The amyloid hypothesis on trial
    Lowe D. Faked Beta-Amyloid Data. What Does It Mean?.  In the Pipeline, https://www.science.org/content/blog-post/faked-beta-amyloid-data-what-does-it-mean
    Makin S. The amyloid hypothesis on trial. (2018)  Nature, 559 (7715): S4-S7. [PMID:30046080]
    Piller C. Blots on a field?. (2022)  Science, 377 (6604): 358-363. [PMID:35862524]

  • The role of free fatty acid receptor pathways in a selective regulation of TRPA1 and TRPV1 by resolvins in primary sensory neurons.
    Pyo HJ, An X, Cho H. The role of free fatty acid receptor pathways in a selective regulation of TRPA1 and TRPV1 by resolvins in primary sensory neurons. (2022)  J Cell Physiol, [Epub ahead of print]. [PMID:35802479]

  • Maresin 2 is an analgesic specialized pro-resolution lipid mediator in mice by inhibiting neutrophil and monocyte recruitment, nociceptor neuron TRPV1 and TRPA1 activation, and CGRP release.
    Fattori V, Zaninelli TH, Ferraz CR, Brasil-Silva L, Borghi SM, Cunha JM, Chichorro JG, Casagrande R, Verri Jr WA. Maresin 2 is an analgesic specialized pro-resolution lipid mediator in mice by inhibiting neutrophil and monocyte recruitment, nociceptor neuron TRPV1 and TRPA1 activation, and CGRP release. (2022)  Neuropharmacology, 216: 109189 [Epub ahead of print]. [PMID:35820471]

  • GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
    Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsøe K, Li H, Zhang Y et al.. GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. (2022)  Mol Cell, [Epub ahead of print]. [PMID:35714614]

  • Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells.
    Zhang YW, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N, Jäcklein K et al.. Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells. (2022)  Nat Cell Biol, [Epub ahead of print]. DOI: 10.1038/s41556-022-00931-x [PMID:35725769]

  • GPR15L is an epithelial inflammation-derived pruritogen.
    Tseng PY, Hoon MA. GPR15L is an epithelial inflammation-derived pruritogen. (2022)  Sci Adv, 8 (24): eabm7342. DOI: 10.1126/sciadv.abm7342 [PMID:35704588]

  • TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
    Gao Y, Ma R, Weng W, Zhang H, Wang Y, Guo R, Gu X, Yang Y, Yang F, Zhou A et al.. TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors. (2022)  Cell Rep, 39 (11): 110972. [PMID:35705043]

  • An exercise-inducible metabolite that suppresses feeding and obesity.
    Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, Tanzo JT, Tung AS, Lyu X, Zushin PH et al.. An exercise-inducible metabolite that suppresses feeding and obesity. (2022)  Nature, 606 (7915): 785-790. [PMID:35705806]

  • June 2022


  • The LOTUS initiative for open knowledge management in natural products research.
    Rutz A, Sorokina M, Galgonek J, Mietchen D, Willighagen E, Gaudry A, Graham JG, Stephan R, Page R, Vondrášek J et al.. The LOTUS initiative for open knowledge management in natural products research. (2022)  Elife, 11. [PMID:35616633]

  • A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
    Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria PM, Saxena AR, Bagley SW, Buckeridge C, Curto JM et al.. A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor. (2022)  J Med Chem, 65 (12): 8208-8226. [PMID:35647711]

  • Tirzepatide Once Weekly for the Treatment of Obesity.
    Jastreboff AM, Aronne JL, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC et al.. Tirzepatide Once Weekly for the Treatment of Obesity. (2022)  New England Journal of Medicine, Epub ahead of print. DOI: 10.1056/NEJMoa2206038 [PMID:35658024]

  • Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
    Lopez JP, Lücken MD, Brivio E, Karamihalev S, Kos A, De Donno C, Benjamin A, Yang H, Dick ALW, Stoffel R et al.. Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. (2022)  Neuron, [Epub ahead of print]. [PMID:35649415]

  • Phenotypic drug discovery: recent successes, lessons learned and new directions
    Lowe D. Modern Phenotypic Drug Discovery.  In the Pipeline, https://www.science.org/content/blog-post/modern-phenotypic-drug-discovery
    Vincent F, Nueda A, Lee J, Schenone M, Prunotto M, Mercola M. Phenotypic drug discovery: recent successes, lessons learned and new directions. (2022)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:35637317]

  • May 2022


  • Profiling the Human Phosphoproteome to Estimate the True Extent of Protein Phosphorylation.
    Kalyuzhnyy A, Eyers PA, Eyers CE, Bowler-Barnett E, Martin MJ, Sun Z, Deutsch EW, Jones AR. Profiling the Human Phosphoproteome to Estimate the True Extent of Protein Phosphorylation. (2022)  J Proteome Res, [Epub ahead of print]. [PMID:35532924]

  • Neuroscience-based nomenclature of psychotropics: Progress report.
    Zohar J, Levy DM. Neuroscience-based nomenclature of psychotropics: Progress report. (2022)  Eur Neuropsychopharmacol, 57: 36-38. [PMID:35077943]

  • Mapping cell types across human tissues
    Domínguez Conde C, Xu C, Jarvis LB, Rainbow DB, Wells SB, Gomes T, Howlett SK, Suchanek O, Polanski K, King HW et al.. Cross-tissue immune cell analysis reveals tissue-specific features in humans. (2022)  Science, 376 (6594): eabl5197. [PMID:35549406]
    Liu Z, Zhang Z. Mapping cell types across human tissues. (2022)  Science, 376 (6594): 695-696. [PMID:35549410]
    Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P et al.. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. (2022)  Science, 376 (6594): eabl4896. [PMID:35549404]

  • Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation.
    Warrier T, Romano KP, Clatworthy AE, Hung DT. Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation. (2022)  Cell Chem Biol, [Epub ahead of print]. [PMID:35523184]

  • Control of host PTMs by intracellular bacteria: An opportunity toward novel anti-infective agents.
    Stévenin V, Neefjes J. Control of host PTMs by intracellular bacteria: An opportunity toward novel anti-infective agents. (2022)  Cell Chem Biol, [Epub ahead of print]. [PMID:35512694]

  • Gene regulation by gonadal hormone receptors underlies brain sex differences.
    Gegenhuber B, Wu MV, Bronstein R, Tollkuhn J. Gene regulation by gonadal hormone receptors underlies brain sex differences. (2022)  Nature, [Epub ahead of print]. [PMID:35508660]

  • Trends in innovative drug development in China.
    Su X, Wang H, Zhao N, Wang T, Cui Y. Trends in innovative drug development in China. (2022)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:35513561]

  • Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties.
    Palacios-Prado N, Soto PA, López X, Choi EJ, Marquez-Miranda V, Rojas M, Duarte Y, Lee J, González-Nilo FD, Sáez JC. Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties. (2022)  Proc Natl Acad Sci U S A, 119 (18): e2202104119. [PMID:35486697]

  • TLR7 and Lupus.
    Lowe D. TLR7 and Lupus. 
    Accessed on 16/05/2022. Modified on 16/05/2022. In the Pipeline, https://www.science.org/content/blog-post/tlr7-and-lupus

  • Physicochemical classification of organisms.
    Vallina Estrada E, Oliveberg M. Physicochemical classification of organisms. (2022)  Proc Natl Acad Sci U S A, 119 (19): e2122957119. [PMID:35500111]

  • April 2022


  • The complete sequence of a human genome
    Church DM. A next-generation human genome sequence. (2022)  Science, 376 (6588): 34-35. [PMID:35357937]
    Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze AV, Mikheenko A, Vollger MR, Altemose N, Uralsky L, Gershman A et al.. The complete sequence of a human genome. (2022)  Science, 376 (6588): 44-53. [PMID:35357919]

  • Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
    de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA, Rubiano K, Striepen J, Abla N, Berning L et al.. Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. (2022)  Nat Commun, 13 (1): 2158. [PMID:35444200]

  • Emergence of new subgenomic mRNAs in SARS-CoV-2.
    Mears HV, Young GR, Sanderson T, Harvey R, Crawford M, Snell DM, Fowler AS, Hussain S, Nicod J, Peacock TP et al.. Emergence of new subgenomic mRNAs in SARS-CoV-2. (2022)  bioRxiv, Preprint. DOI: 10.1101/2022.04.20.488895

  • Novel drug targets in 2021.
    Avram S, Halip L, Curpan R, Oprea TI. Novel drug targets in 2021. (2022)  Nat Rev Drug Discov, [Epub ahead of print]. [PMID:35361900]

  • Hot Topics: A new study shows that human ageing is absolutely precise, when disease is eliminated, and accompanied by a disintegration of metabolic efficiency

    Comments by the Guide to Pharmacology Curation Team, University of Edinburgh

    Hot Topics: A new study shows that human ageing is absolutely precise, when disease is eliminated, and accompanied by a disintegration of metabolic efficiency. Read the full article on our blog

  • Hot Topics: Endothelin-1 pathway, a new therapeutic target for COVID-19

    Comments by the Guide to Pharmacology Curation Team, University of Edinburgh

    SARS-CoV-2 gains entry into the body mainly via the lungs. After entering the blood, the virus rapidly multiplies to infect nearby cells. Endothelial cells line every blood vessel and have a surface area similar to a tennis court. These cells are especially vulnerable to virus infection as they express the the virus entry receptor, ACE2. Endothelial cells are also a source of endothelin-1 (ET-1), which is released in response to injury to cause long lasting vasoconstriction, reducing oxygen supply to vital organs. In the lungs, this can cause breathing difficulty, which in severe cases requires patients to be given oxygen and put on a ventilator.. Read the full article on our blog

  • Structural Perspective on the Mechanism of Signal Activation, Ligand Selectivity and Allosteric Modulation in Angiotensin Receptors: IUPHAR Review 34.
    Singh KD, Karnik SS. Structural Perspective on the Mechanism of Signal Activation, Ligand Selectivity and Allosteric Modulation in Angiotensin Receptors: IUPHAR Review 34. (2022)  Br J Pharmacol, [Epub ahead of print]. DOI: 10.1111/bph.15840 [PMID:35318654]

  • Eicosanoid signaling blockade protects middle-aged mice from severe COVID-19.
    Wong LR, Zheng J, Wilhelmsen K, Li K, Ortiz ME, Schnicker NJ, Thurman A, Pezzulo AA, Szachowicz PJ, Li P et al.. Eicosanoid signaling blockade protects middle-aged mice from severe COVID-19. (2022)  Nature, [Epub ahead of print]. DOI: 10.1038/s41586-022-04630-3 [PMID:35314834]

  • A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
    Guide to Pharmacology Curation Team. Database Release 2022.1.  guidetopharmacology blog, https://blog.guidetopharmacology.org/2022/03/31/database-release-2022-1/#N-0385
    Shapira T, Monreal IA, Dion SP, Buchholz DW, Imbiakha B, Olmstead AD, Jager M, Désilets A, Gao G, Martins M et al.. A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic. (2022)  Nature, [Epub ahead of print]. DOI: 10.1038/s41586-022-04661-w [PMID:35344983]

  • March 2022


  • Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor.
    Mishra I, Xie WR, Bournat JC, He Y, Wang C, Silva ES, Liu H, Ku Z, Chen Y, Erokwu BO et al.. Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor. (2022)  Cell Metab, [Epub ahead of print]. [PMID:35298903]

  • International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update.
    IJzerman AP, Jacobson KA, Müller CE, Cronstein BN, Cunha RA. International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update. (2022)  Pharmacol Rev, 74 (2): 340-372. [PMID:35302044]

  • Common coupling map advances GPCR-G protein selectivity.
    Hauser AS, Avet C, Normand C, Mancini A, Inoue A, Bouvier M, Gloriam DE. Common coupling map advances GPCR-G protein selectivity. (2022)  Elife, 11 [Epub ahead of print]. [PMID:35302494]

  • Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.
    Avet C, Mancini A, Breton B, Le Gouill C, Hauser AS, Normand C, Kobayashi H, Gross F, Hogue M, Lukasheva V et al.. Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs. (2022)  Elife, 11 [Epub ahead of print]. [PMID:35302493]

  • Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.
    Chang A, Xiang X, Wang J, Lee C, Arakhamia T, Simjanoska M, Wang C, Carlomagno Y, Zhang G, Dhingra S et al.. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. (2022)  Cell, [Epub ahead of print]. [PMID:35247328]

  • Structural insights into ligand recognition, activation, and signaling of the α2A adrenergic receptor.
    Xu J, Cao S, Hübner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y. Structural insights into ligand recognition, activation, and signaling of the α2A adrenergic receptor. (2022)  Sci Adv, 8 (9): eabj5347. [PMID:35245122]

  • Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter.
    Higuchi K, Sugiyama K, Tomabechi R, Kishimoto H, Inoue K. Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter. (2022)  J Biol Chem,: 101800 [Epub ahead of print]. [PMID:35257743]

  • Targeting solute carriers to modulate receptor-ligand interactions.
    Sijben HJ, Superti-Furga G, IJzerman AP, Heitman LH. Targeting solute carriers to modulate receptor-ligand interactions. (2022)  Trends Pharmacol Sci, [Epub ahead of print]. [PMID:35232590]

  • High-throughput metabolomics predicts drug-target relationships for eukaryotic proteins.
    Holbrook-Smith D, Durot S, Sauer U. High-throughput metabolomics predicts drug-target relationships for eukaryotic proteins. (2022)  Mol Syst Biol, 18 (2): e10767. [PMID:35194925]

  • Systematic illumination of druggable genes in cancer genomes.
    Jiang J, Yuan J, Hu Z, Zhang Y, Zhang T, Xu M, Long M, Fan Y, Tanyi JL, Montone KT et al.. Systematic illumination of druggable genes in cancer genomes. (2022)  Cell Rep, 38 (8): 110400. [PMID:35196490]

  • Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis.
    Chen LH, Zhang Q, Xiao YF, Fang YC, Xie X, Nan FJ. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. (2022)  J Med Chem, [Epub ahead of print]. [PMID:35195005]

  • Conserved hydrogen-bond motifs of membrane transporters and receptors.
    Lazaratos M, Siemers M, Brown LS, Bondar AN. Conserved hydrogen-bond motifs of membrane transporters and receptors. (2022)  Biochim Biophys Acta Biomembr, 1864 (6): 183896 [Epub ahead of print]. [PMID:35217000]

  • February 2022


  • Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2.
    Matsuoka R, Fudim R, Jung S, Zhang C, Bazzone A, Chatzikyriakidou Y, Robinson CV, Nomura N, Iwata S, Landreh M et al.. Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2. (2022)  Nat Struct Mol Biol, 29 (2): 108-120. [PMID:35173351]

  • Pharmaceutical pollution of the world's rivers.
    Wilkinson JL, Boxall ABA, Kolpin DW, Leung KMY, Lai RWS, Galbán-Malagón C, Adell AD, Mondon J, Metian M, Marchant RA et al.. Pharmaceutical pollution of the world's rivers. (2022)  Proc Natl Acad Sci U S A, 119 (8). [PMID:35165193]

  • Structural Insights into Molecular Recognition by Human Chemokine CCL19.
    Lewandowski EM, Kroeck KG, Jacobs LMC, Fenske TG, Witt RN, Hintz AM, Ramsden ER, Zhang X, Peterson F, Volkman BF et al.. Structural Insights into Molecular Recognition by Human Chemokine CCL19. (2022)  Biochemistry, [Epub ahead of print]. [PMID:35156805]

  • Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors.
    Tavares-Ferreira D, Shiers S, Ray PR, Wangzhou A, Jeevakumar V, Sankaranarayanan I, Cervantes AM, Reese JC, Chamessian A, Copits BA et al.. Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors. (2022)  Sci Transl Med, 14 (632): eabj8186. [PMID:35171654]

  • Hot Topics: SARS-CoV-2 and the truncated ACE-2 variant

    Comments by Christopher Southan, Data Science, Medicines Discovery Catapult and Honorary Fellow, University of Edinburgh.

    ACE2 normally functions as an enzyme metabolising peptides that regulate the cardiovascular system but also acts as a receptor for SARS-CoV-2. This study compared the distribution in human tissue of ACE2 versus deltaACE2, a recently discovered truncated isoform that has lost the spike binding sites for SARS-CoV-2, and is predicted to confer reduced susceptibility to viral infection. ACE2 was highly expressed in human lung, kidney, heart, liver and vasculature. However, deltaACE2 was the predominant isoform in lung airway and liver bile duct epithelia, which may be a contributing factor to variation in response to the virus.. Read the full article on our blog

  • Mechanism of CFTR correction by type I folding correctors.
    Fiedorczuk K, Chen J. Mechanism of CFTR correction by type I folding correctors. (2022)  Cell, 185 (1): 158-168.e11. [PMID:34995514]

  • P2X4 and P2X7 are essential players in basal T cell activity and Ca2+ signaling milliseconds after T cell activation.
    Brock VJ, Wolf IMA, Er-Lukowiak M, Lory N, Stähler T, Woelk LM, Mittrücker HW, Müller CE, Koch-Nolte F, Rissiek B et al.. P2X4 and P2X7 are essential players in basal T cell activity and Ca2+ signaling milliseconds after T cell activation. (2022)  Sci Adv, 8 (5): eabl9770. [PMID:35119925]

  • Community Guidelines for GPCR Ligand Bias: IUPHAR Review 32.
    Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov K et al.. Community Guidelines for GPCR Ligand Bias: IUPHAR Review 32. (2022)  Br J Pharmacol, [Epub ahead of print]. [PMID:35106752]

  • Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.
    Hochheiser IV, Pilsl M, Hagelueken G, Moecking J, Marleaux M, Brinkschulte R, Latz E, Engel C, Geyer M. Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3. (2022)  Nature, [Epub ahead of print]. [PMID:35114687]

  • January 2022


  • Structure and transport mechanism of the human cholesterol transporter ABCG1.
    Xu D, Li Y, Yang F, Sun CR, Pan J, Wang L, Chen ZP, Fang SC, Yao X, Hou WT et al.. Structure and transport mechanism of the human cholesterol transporter ABCG1. (2022)  Cell Rep, 38 (4): 110298. [PMID:35081353]

  • Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.
    Tyagi A, Ahmed T, Jian S, Bajaj S, Ong ST, Goay SSM, Zhao Y, Vorobyov I, Tian C, Chandy KG et al.. Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. (2022)  Proc Natl Acad Sci U S A, 119 (5). [PMID:35091471]

  • Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy.
    Laurila PP, Luan P, Wohlwend M, Zanou N, Crisol B, Imamura de Lima T, Goeminne LJE, Gallart-Ayala H, Shong M, Ivanisevic J et al.. Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy. (2022)  Sci Adv, 8 (4): eabh4423. [PMID:35089797]

  • The cGAS-STING pathway drives type I IFN immunopathology in COVID-19.
    Di Domizio J, Gulen MF, Saidoune F, Thacker VV, Yatim A, Sharma K, Nass T, Guenova E, Schaller M, Conrad C et al.. The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. (2022)  Nature, [Epub ahead of print]. DOI: 10.1038/s41586-022-04421-w [PMID:35045565]

  • AI in health and medicine.
    Rajpurkar P, Chen E, Banerjee O, Topol EJ. AI in health and medicine. (2022)  Nat Med, [Epub ahead of print]. [PMID:35058619]

  • Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
    Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L. Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. (2022)  Neuron, [Epub ahead of print]. [PMID:35051376]

  • NO rapidly mobilizes cellular heme to trigger assembly of its own receptor.
    Dai Y, Faul EM, Ghosh A, Stuehr DJ. NO rapidly mobilizes cellular heme to trigger assembly of its own receptor. (2022)  Proc Natl Acad Sci U S A, 119 (4). [PMID:35046034]

  • A guide to immunotherapy for COVID-19.
    van de Veerdonk FL, Giamarellos-Bourboulis E, Pickkers P, Derde L, Leavis H, van Crevel R, Engel JJ, Wiersinga WJ, Vlaar APJ, Shankar-Hari M et al.. A guide to immunotherapy for COVID-19. (2022)  Nat Med, [Epub ahead of print]. [PMID:35064248]

  • Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.
    Bjornevik K, Cortese M, Healy BC, Kuhle J, Mina MJ, Leng Y, Elledge SJ, Niebuhr DW, Scher AI, Munger KL et al.. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. (2022)  Science, [Epub ahead of print]. [PMID:35025605]

  • December 2021


  • Synthon-based ligand discovery in virtual libraries of over 11 billion compounds.
    Sadybekov AA, Sadybekov AV, Liu Y, Iliopoulos-Tsoutsouvas C, Huang XP, Pickett J, Houser B, Patel N, Tran NK, Tong F et al.. Synthon-based ligand discovery in virtual libraries of over 11 billion compounds. (2021)  Nature, [Epub ahead of print]. [PMID:34912117]

  • Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain.
    van der Vlist M, Raoof R, Willemen HLDM, Prado J, Versteeg S, Martin Gil C, Vos M, Lokhorst RE, Pasterkamp RJ, Kojima T et al.. Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain. (2021)  Neuron, [Epub ahead of print]. [PMID:34921782]

  • Structure-Based Virtual Screening for Ligands of G Protein-Coupled Receptors: What Can Molecular Docking Do for You?.
    Ballante F, Kooistra AJ, Kampen S, de Graaf C, Carlsson J. Structure-Based Virtual Screening for Ligands of G Protein-Coupled Receptors: What Can Molecular Docking Do for You?. (2021)  Pharmacol Rev, 73 (4): 527-565. [PMID:34907092]

  • Aprepitant is a novel, selective activator of the K2P channel TRAAK.
    McCoull D, Veale EL, Walsh Y, Byrom L, Avkiran T, Large JM, Vaitone E, Gaffey F, Jerman J, Mathie A, Wright PD. Aprepitant is a novel, selective activator of the K2P channel TRAAK. (2022)  BBRC, 588: 41-46 [Epub ahead of print]. DOI: 10.1016/j.bbrc.2021.12.031

  • Structures of the σ2 receptor enable docking for bioactive ligand discovery.
    Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP et al.. Structures of the σ2 receptor enable docking for bioactive ligand discovery. (2021)  Nature, [Epub ahead of print]. [PMID:34880501]

  • Structure and mechanism of the SGLT family of glucose transporters.
    Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L. Structure and mechanism of the SGLT family of glucose transporters. (2021)  Nature, [Epub ahead of print]. [PMID:34880492]

  • Key cancer results failed to be reproduced.
    Kaiser J. Key cancer results failed to be reproduced. (2021)  Science, 374 (6573): 1311. [PMID:34882444]

  • Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter.
    Niu Y, Liu R, Guan C, Zhang Y, Chen Z, Hoerer S, Nar H, Chen L. Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter. (2021)  Nature, [Epub ahead of print]. [PMID:34880493]

  • A hormone complex of FABP4 and nucleoside kinases regulates islet function.
    Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P et al.. A hormone complex of FABP4 and nucleoside kinases regulates islet function. (2021)  Nature, [Epub ahead of print]. [PMID:34880500]

  • From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
    Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD et al.. From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. (2021)  Cell, 184 (24): 5886-5901.e22. [PMID:34822784]