Database content

Current database content for version 2025.1 released 01 April 2025.

Target ClassNumber of human targets‡
7TM receptors399
G protein-coupled receptors including orphans394
Orphan G protein-coupled receptors*121
Other 7TM proteins5
Nuclear hormone receptors48
Catalytic receptors253
Ligand-gated ion channels81
Voltage-gated ion channels144
Other ion channels53
Enzymes1310
Transporters555
Other protein targets254
Total number of targets3097
Chemical ClassNumber of ligands
Synthetic organics9244
Metabolites513
Endogenous peptides822
Other peptides including synthetic peptides1536
Natural Products502
Antibodies433
Inorganics39
Approved drugs2098
Withdrawn drugs113
Drugs with INNs3701
Labelled ligands649
Total number of ligands13130
CategoryCount in database
Total curated interactions23652
Total quantitative interactions21491
Number of unique target-ligand pairs19472
Number of curated binding constants21491
Number of binding constants from large-scale screens31207
Number of references47012
Human targets with curated interactions2015
Human targets with quantitative interactions1758
Human targets with quantitative interactions with CIDs1588
Human targets of approved drugs755
Human primary targets of approved drugs355
Approved drugs with quantitative interactions1175
Ligands with target interactions10728
Ligands with quantitative interactions9485
Ligands with CID and quantitative interactions8057
Ligands with clinical use summary3996
Approved drugs with clincial use summary2098
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‡ Measured by the number of distinct human UniProt entries included in the database for a given target class.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.