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Database content
Current database content for version 2026.2 released 15 June 2026.
| Target Class | Number of human targets‡ |
|---|---|
| 7TM receptors | 400 |
| G protein-coupled receptors including orphans | 396 |
| Orphan G protein-coupled receptors* | 41 |
| Other 7TM proteins | 4 |
| Nuclear hormone receptors | 48 |
| Catalytic receptors | 253 |
| Ligand-gated ion channels | 81 |
| Voltage-gated ion channels | 144 |
| Other ion channels | 55 |
| Enzymes | 1331 |
| Transporters | 555 |
| Other protein targets | 274 |
| Total number of targets | 3141 |
| Chemical Class | Number of ligands |
|---|---|
| Synthetic organics | 9753 |
| Metabolites | 514 |
| Endogenous peptides | 837 |
| Other peptides including synthetic peptides | 1615 |
| Natural Products | 558 |
| Antibodies | 495 |
| Inorganics | 39 |
| Approved drugs | 2218 |
| Withdrawn drugs | 118 |
| Drugs with INNs | 3939 |
| Labelled ligands | 662 |
| Total number of ligands | 13856 |
| Category | Count in database |
|---|---|
| Total curated interactions | 24599 |
| Total quantitative interactions | 22316 |
| Number of unique target-ligand pairs | 20258 |
| Number of curated binding constants | 22316 |
| Number of binding constants from large-scale screens | 31207 |
| Number of references | 49913 |
| Human targets with curated interactions | 2086 |
| Human targets with quantitative interactions | 1823 |
| Human targets with quantitative interactions with CIDs | 1639 |
| Human targets of approved drugs | 777 |
| Human primary targets of approved drugs | 361 |
| Approved drugs with quantitative interactions | 1251 |
| Ligands with target interactions | 11313 |
| Ligands with quantitative interactions | 9984 |
| Ligands with CID and quantitative interactions | 8444 |
| Ligands with clinical use summary | 4325 |
| Approved drugs with clincial use summary | 2216 |
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‡ Measured by the number of distinct human UniProt entries included in the database for a given target class.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.
