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Database content

Current database content for version 2025.2 released 18 June 2025.

Target ClassNumber of human targets
7TM receptors399
G protein-coupled receptors including orphans395
Orphan G protein-coupled receptors*41
Other 7TM proteins4
Nuclear hormone receptors48
Catalytic receptors253
Ligand-gated ion channels81
Voltage-gated ion channels144
Other ion channels53
Enzymes1315
Transporters555
Other protein targets255
Total number of targets3103
Chemical ClassNumber of ligands
Synthetic organics9329
Metabolites513
Endogenous peptides824
Other peptides including synthetic peptides1545
Natural Products521
Antibodies447
Inorganics39
Approved drugs2120
Withdrawn drugs116
Drugs with INNs3734
Labelled ligands649
Total number of ligands13260
CategoryCount in database
Total curated interactions23827
Total quantitative interactions21643
Number of unique target-ligand pairs19613
Number of curated binding constants21643
Number of binding constants from large-scale screens31207
Number of references47380
Human targets with curated interactions2027
Human targets with quantitative interactions1767
Human targets with quantitative interactions with CIDs1596
Human targets of approved drugs757
Human primary targets of approved drugs355
Approved drugs with quantitative interactions1191
Ligands with target interactions10835
Ligands with quantitative interactions9571
Ligands with CID and quantitative interactions8118
Ligands with clinical use summary4053
Approved drugs with clincial use summary2119
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Measured by the number of distinct human UniProt entries included in the database for a given target class.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.