Database content

Current database content for version 2024.4 released 04 December 2024.

Target ClassNumber of human targets‡
7TM receptors399
G protein-coupled receptors including orphans394
Orphan G protein-coupled receptors*122
Other 7TM proteins5
Nuclear hormone receptors48
Catalytic receptors253
Ligand-gated ion channels81
Voltage-gated ion channels144
Other ion channels53
Enzymes1309
Transporters555
Other protein targets247
Total number of targets3089
Chemical ClassNumber of ligands
Synthetic organics9143
Metabolites512
Endogenous peptides819
Other peptides including synthetic peptides1525
Natural Products475
Antibodies401
Inorganics39
Approved drugs2038
Withdrawn drugs113
Drugs with INNs3576
Labelled ligands649
Total number of ligands12950
CategoryCount in database
Total curated interactions23474
Total quantitative interactions21330
Number of unique target-ligand pairs19332
Number of curated binding constants21330
Number of binding constants from large-scale screens31207
Number of references46431
Human targets with curated interactions2002
Human targets with quantitative interactions1750
Human targets with quantitative interactions with CIDs1582
Human targets of approved drugs751
Human primary targets of approved drugs353
Approved drugs with quantitative interactions1140
Ligands with target interactions10619
Ligands with quantitative interactions9392
Ligands with CID and quantitative interactions7974
Ligands with clinical use summary3876
Approved drugs with clincial use summary2038
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‡ Measured by the number of distinct human UniProt entries included in the database for a given target class.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.