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Database content
Current database content for version 2026.1 released 12 March 2026.
| Target Class | Number of human targets‡ |
|---|---|
| 7TM receptors | 400 |
| G protein-coupled receptors including orphans | 396 |
| Orphan G protein-coupled receptors* | 41 |
| Other 7TM proteins | 4 |
| Nuclear hormone receptors | 48 |
| Catalytic receptors | 253 |
| Ligand-gated ion channels | 81 |
| Voltage-gated ion channels | 144 |
| Other ion channels | 55 |
| Enzymes | 1326 |
| Transporters | 555 |
| Other protein targets | 265 |
| Total number of targets | 3127 |
| Chemical Class | Number of ligands |
|---|---|
| Synthetic organics | 9672 |
| Metabolites | 514 |
| Endogenous peptides | 834 |
| Other peptides including synthetic peptides | 1599 |
| Natural Products | 543 |
| Antibodies | 482 |
| Inorganics | 39 |
| Approved drugs | 2197 |
| Withdrawn drugs | 117 |
| Drugs with INNs | 3901 |
| Labelled ligands | 662 |
| Total number of ligands | 13727 |
| Category | Count in database |
|---|---|
| Total curated interactions | 24458 |
| Total quantitative interactions | 22198 |
| Number of unique target-ligand pairs | 20139 |
| Number of curated binding constants | 22198 |
| Number of binding constants from large-scale screens | 31207 |
| Number of references | 49320 |
| Human targets with curated interactions | 2068 |
| Human targets with quantitative interactions | 1808 |
| Human targets with quantitative interactions with CIDs | 1635 |
| Human targets of approved drugs | 772 |
| Human primary targets of approved drugs | 357 |
| Approved drugs with quantitative interactions | 1239 |
| Ligands with target interactions | 11212 |
| Ligands with quantitative interactions | 9900 |
| Ligands with CID and quantitative interactions | 8406 |
| Ligands with clinical use summary | 4259 |
| Approved drugs with clincial use summary | 2196 |
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‡ Measured by the number of distinct human UniProt entries included in the database for a given target class.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.
