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Current database content for version 2025.2 released 18 June 2025.
Target Class | Number of human targets‡ |
---|---|
7TM receptors | 399 |
G protein-coupled receptors including orphans | 395 |
Orphan G protein-coupled receptors* | 41 |
Other 7TM proteins | 4 |
Nuclear hormone receptors | 48 |
Catalytic receptors | 253 |
Ligand-gated ion channels | 81 |
Voltage-gated ion channels | 144 |
Other ion channels | 53 |
Enzymes | 1315 |
Transporters | 555 |
Other protein targets | 255 |
Total number of targets | 3103 |
Chemical Class | Number of ligands |
---|---|
Synthetic organics | 9329 |
Metabolites | 513 |
Endogenous peptides | 824 |
Other peptides including synthetic peptides | 1545 |
Natural Products | 521 |
Antibodies | 447 |
Inorganics | 39 |
Approved drugs | 2120 |
Withdrawn drugs | 116 |
Drugs with INNs | 3734 |
Labelled ligands | 649 |
Total number of ligands | 13260 |
Category | Count in database |
---|---|
Total curated interactions | 23827 |
Total quantitative interactions | 21643 |
Number of unique target-ligand pairs | 19613 |
Number of curated binding constants | 21643 |
Number of binding constants from large-scale screens | 31207 |
Number of references | 47380 |
Human targets with curated interactions | 2027 |
Human targets with quantitative interactions | 1767 |
Human targets with quantitative interactions with CIDs | 1596 |
Human targets of approved drugs | 757 |
Human primary targets of approved drugs | 355 |
Approved drugs with quantitative interactions | 1191 |
Ligands with target interactions | 10835 |
Ligands with quantitative interactions | 9571 |
Ligands with CID and quantitative interactions | 8118 |
Ligands with clinical use summary | 4053 |
Approved drugs with clincial use summary | 2119 |
‡ Measured by the number of distinct human UniProt entries included in the database for a given target class.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.